Beta-2-microglobulin antibody

Principal name

Beta-2-microglobulin antibody

Alternative names for Beta-2-microglobulin antibody

B2M, Beta-2 microglobulin, Beta 2 microglobulin

SwissProt ID

P01887 (Mouse), P01888 (Bovin), P07151 (Rat), P21611 (Chick), P61769 (Human), Q07717 (Pig)

Gene ID

567 (B2M), 24223 (B2m)

Available reactivities

Hu (Human), Por (Porcine), Rt (Rat), Chk (Chicken), Bov (Bovine), Ms (Mouse)

Available hosts

Mouse, Rabbit, Sheep, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), Radioimmunoassay (R), Paraffin Sections (P), Immunoelectron Microscopy (EM), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), EPair for Elisa (EPair)

Background of Beta-2-microglobulin antibody

ß2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a terry membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system. As an integral component of the MHC class I complex,ß2-microglobulin plays a critically important role in immune system function. It has important relevance to cancer biology research; for example, research studies have shown that nearly one-third of diffuse large B cell lymphomas contain mutations that ictivate ß2-microglobulin gene function, thereby allowing tumor cells to escape immune detection. In additon,ß2-microglobulin has been identified as an amyloid preprotein with collagen-binding affinity; its accumulation in osteoarthritic lesions of long-term dialysis patients is reportedly a contributing factor to the condition known as amyloid osteoarthropathy.

General readings

1. Hilgert I, Horejsi V, Kristofova H.: The use of murine monoclonal antibody B2M-01 for
detection and purification of human beta 2-microglobulin. Folia Biol (Praha). 1984;30(6):369-76.
2. Drbal K, Angelisova P, Hilgert I, Cerny J, Novak P, Horejsi V.: A proteolytically truncated
form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated
myeloid cells. Blood. 2001 Sep 1;98(5):1561-6.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Beta-2-microglobulin antibody

Stainning of methanol-fixed Hela cells: Mouse anti-Human beta 2 Microglobulin monoclonal antibody (D2A10) 1/50 (20 µg/ml). Mouse IgG1 D2A10 Aff - Purified Hu E, F, ICC/IF, WB
0.5 mg / $470.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Staining of methanol-fixed Hela cells by Immunocytochemistry: Mouse anti-Human beta 2 Microglobulin monoclonal antibody (D3A2) 1:50 (20 µg/ml). Mouse IgG1 D3A2 Aff - Purified Hu E, E(detection), F, ICC/IF, WB
0.5 mg / $470.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Beta-2-microglobulin Mouse IgG1 D2E9 HRP E
0.2 ml / $510.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Human Prostate (formalin-fixed, paraffin-embedded) stained with B2M antibody AM20523PU-N at 10 µg/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 n.a Purified Hu P
50 µg / $425.00
  OriGene Technologies GmbH

Beta-2-microglobulin (N-term) antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with B2M antibody (N-term) (Cat.#AP12414PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P
0.4 ml / $415.00
  OriGene Technologies GmbH

Beta-2-microglobulin (C-term) antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with B2M antibody (C-term) (Cat.#AP12415PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P
0.4 ml / $415.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Hu E, P
0.25 mg / $425.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Beta-2-microglobulin Mouse IgG1 2213 Purified Hu C, E, R
1 ml / $560.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Surface staining of β2-microglobulin in human peripheral blood with anti-β2-microglobulin (B2M-01) FITC. Mouse IgG2a B2M-01 FITC Hu F, ICC/IF
0.1 mg / $260.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Western blot analysis (non-reducing conditions) of whole cell lysate of various cell lines using anti-human β2-microglobulin (B2M-01).
Lane 1: RAJI human Burkitt lymphoma cell line
Lane 2: EL4 mouse lymphoblastic lymphoma cell line
Lane 3: U937 human histiocytic lymphoma cell line Mouse IgG2a B2M-01 PE Hu F
0.1 mg / $310.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Beta-2-microglobulin Rabbit Biotin Hu C, E, P, WB
0.1 mg / $515.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Beta-2-microglobulin Rabbit HRP Hu C, E, EM, WB
0.5 mg / $590.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Beta-2-microglobulin Rabbit HRP Hu C, E, P, WB
0.1 mg / $515.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Beta-2-microglobulin Mouse IgG1 TLD-3H12B Purified Rt C, F, WB
0.25 mg / $460.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Beta-2-microglobulin Mouse IgG1 TLD-3H12B Purified Rt C, F
0.1 mg / $330.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Surface staining of human peripheral blood cells by mouse monoclonal anti-beta2-microglobulin antibody B2M-02. Mouse IgG1 B2M-02 Biotin Hu, Por F
0.1 mg / $260.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Surface staining of human peripheral blood cells by mouse monoclonal anti-beta2-microglobulin antibody B2M-02. Mouse IgG1 B2M-02 Purified Hu, Por E, F, P, WB
0.1 mg / $210.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

COP5 transiently transfected with Beta-2-microglobulin cDNA stained by clone mAb4 Mouse IgM mAb4 Purified Hu E, E(capture), F
0.1 mg / $440.00
  Dendritics SAS

CRISPR

Catalog No. Species Donor Vector  

B2M - human gene knockout kit via CRISPR

B2M - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / $1,290.00
  OriGene Technologies, Inc.

B2M - human gene knockout kit via CRISPR

B2M - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / $1,290.00
  OriGene Technologies, Inc.

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