Beta-2-microglobulin antibody

Principal name

Beta-2-microglobulin antibody

Alternative names for Beta-2-microglobulin antibody

B2M, Beta-2 microglobulin, Beta 2 microglobulin

SwissProt ID

P01887 (Mouse), P01888 (Bovin), P07151 (Rat), P21611 (Chick), P61769 (Human), Q07717 (Pig)

Gene ID

567 (B2M), 24223 (B2m)

Available reactivities

Hu (Human), Por (Porcine), Rt (Rat), Chk (Chicken), Bov (Bovine), Ms (Mouse)

Available hosts

Mouse, Rabbit, Sheep, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), Radioimmunoassay (R), Paraffin Sections (P), Immunoelectron Microscopy (EM), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), EPair for Elisa (EPair)

Background of Beta-2-microglobulin antibody

ß2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a terry membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system. As an integral component of the MHC class I complex,ß2-microglobulin plays a critically important role in immune system function. It has important relevance to cancer biology research; for example, research studies have shown that nearly one-third of diffuse large B cell lymphomas contain mutations that ictivate ß2-microglobulin gene function, thereby allowing tumor cells to escape immune detection. In additon,ß2-microglobulin has been identified as an amyloid preprotein with collagen-binding affinity; its accumulation in osteoarthritic lesions of long-term dialysis patients is reportedly a contributing factor to the condition known as amyloid osteoarthropathy.

General readings

1. Hilgert I, Horejsi V, Kristofova H.: The use of murine monoclonal antibody B2M-01 for
detection and purification of human beta 2-microglobulin. Folia Biol (Praha). 1984;30(6):369-76.
2. Drbal K, Angelisova P, Hilgert I, Cerny J, Novak P, Horejsi V.: A proteolytically truncated
form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated
myeloid cells. Blood. 2001 Sep 1;98(5):1561-6.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Beta-2-microglobulin antibody

1. Murine 4T1 cells were mixed with human DU-145 cells and stained with 1 µg Beta-2-microglobulin antibody (BM604S). Anti-mouse Cy3 was used as a secondary antibody. Red stained cells mark the Beta-2-microglobulin positive human DU-145 cells.
2. Murine 4T1 cells were stained with 1 µg Beta-2-microglobulin antibody (BM604S). Anti-mouse Cy3 was used as a secondary antibody. Murine 4T1 cells are negative for Beta-2-microglobulin staining.
Pictures by courtesy of Fraunhofer ITEM, Regensburg, Germany. Mouse IgG2a B2M-01 Purified Hu E, F, ICC/IF, IP, P, R, WB
0.1 mg / $210.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

  Rabbit polyclonal Beta-2-Microglobulin antibody  
IHC of Rabbit anti-Beta-2-Microglobulin Antibody. Tissue: normal human skin. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: Left panel: isotype control, Right panel: ß2 microglobulin antibody at 1 ug/ml for 20 min at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: ß2 microglobulin is cell membrane (and to lesser amount cytoplasmatic compartment). Rabbit Purified Hu C, E, ICC/IF, P, WB
0.1 mg / $515.00
  OriGene Technologies, Inc.

Beta-2-microglobulin antibody

Methanol-fixed Hela cells stained with 20 μg/ml mouse anti-B2MG mAb clone D6E4 and fluorescence labelled secondary antibody. Mouse IgG1 D6E4 Aff - Purified Hu E, ICC/IF
0.5 mg / $470.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Staining of methanol-fixed Hela cells by Immunocytochemistry using Mouse anti-Human beta 2 Microglobulin monoclonal antibody (D2E9) at 1/50 (20 µg/ml). Mouse IgG1 D2E9 Aff - Purified Hu E, E(capture), F, ICC/IF, WB
0.5 mg / $470.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Stainning of methanol-fixed Hela cells: Mouse anti-Human beta 2 Microglobulin monoclonal antibody (D2A10) 1/50 (20 µg/ml). Mouse IgG1 D2A10 Aff - Purified Hu E, F, ICC/IF, WB
0.5 mg / $470.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Staining of methanol-fixed Hela cells by Immunocytochemistry: Mouse anti-Human beta 2 Microglobulin monoclonal antibody (D3A2) 1:50 (20 µg/ml). Mouse IgG1 D3A2 Aff - Purified Hu E, E(detection), F, ICC/IF, WB
0.5 mg / $470.00
  OriGene Technologies GmbH

Beta-2-microglobulin antibody

Surface staining of β2-microglobulin in human peripheral blood with anti-β2-microglobulin (B2M-01) FITC. Mouse IgG2a B2M-01 FITC Hu F, ICC/IF
0.1 mg / $260.00
  OriGene Technologies GmbH

7 Item(s)

per page
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