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AM26803PU-N CD70 antibody

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0.1 mg / $210.00
Delivery Time: 10 working days*
(*) valid for US customers only

View Datasheet

Quick Overview

Mouse anti Human CD70 Ki-24

AM26803PU-N

Product Description for CD70

Mouse anti Human CD70 Ki-24.
Presentation: Purified
Product is tested for Flow Cytometry.

Properties for CD70

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms CD27 ligand, CD27L, CD27LG, TNFSF7, Tumor necrosis factor ligand superfamily member 7
Presentation Purified
Reactivity Hu
Applications F
Clonality Monoclonal
Clone Ki-24
Host Mouse
Isotype IgG3
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P32970
GeneID:
970
Isotype control AM03097PU-N
Application Flow cytometry.
Background CD70, also known as TNFSF7 or CD27L, is a 50 kDa type II transmembrane glycoprotein of the TNF superfamily. It is expressed mainly on activated lymphocytes, including NK cells, and forms trimeric structure. CD70 plays a role in T-cell activation, proliferation and differentiation, in enhancing the generation of cytolytic T cells, and in long-term maintenance of T cell memory. It is also involved in B cell differentiation induced by activated plasmacytoid dendritic cells, which also express CD70.
Concentration 1.0 mg/ml
General Readings
  1. Kaufmann Y, Amariglio N, Rosenthal E, Hirsch YJ, Many A, Rechavi G. Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low-grade lymphoma. J Immunol. 2005 Nov 15;175(10):6940-7. PubMed PMID: 16272354.
  2. Trebing J, El-Mesery M, Schäfer V, Weisenberger D, Siegmund D, Silence K, et al. CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants. Cell Death Dis. 2014 Jan 30;5:e1035. doi: 10.1038/cddis.2013.555. PubMed PMID: 24481449. (Free PMC Article available, 6 images available)
  3. Israel BF, Pickles RJ, Segal DM, Gerard RD, Kenney SC. Enhancement of adenovirus vector entry into CD70-positive B-cell Lines by using a bispecific CD70-adenovirus fiber antibody. J Virol. 2001 Jun;75(11):5215-21. PubMed PMID: 11333903. (Free PMC Article available, 7 images available)
  4. Hashimoto-Okada M, Kitawaki T, Kadowaki N, Iwata S, Morimoto C, Hori T, et al. The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4(+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans. Int Immunol. 2009 Aug;21(8):891-904. doi: 10.1093/intimm/dxp056. Epub 2009 Jun 25. PubMed PMID: 19556308.
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Shelf life: one year from despatch.
Format
Purification:
Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Buffer System:
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
State:
Liquid Ig fraction
Purified
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:
This antibody recognizes CD70, an approximately 50 kDa type II transmembrane glycoprotein expressed on activated lymphocytes and some B cell leukemias.

Accessory Products

Proteins and/or Positive Controls

Proteins for CD70 (9 products)

Catalog No. Species Pres. Purity   Source  

CD70
CD70 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. 		HEK293 cells
20 µg / $748.00
  OriGene Technologies, Inc.

CD70
CD70 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining. 		CHO cells
10 µg / $135.00
  OriGene Technologies, Inc.

CD70
CD70 Human Purified > 95 % by SDS-PAGE gel and HPLC analyses CHO cells
50 µg / $250.00
  OriGene Technologies GmbH

CD70
CD70 Human Purified > 95 % by SDS-PAGE gel and HPLC analyses CHO cells
10 µg / $140.00
  OriGene Technologies GmbH

CD70
CD70 Human Purified > 95 % by SDS-PAGE & HPLC analysis CHO cells
50 µg / $330.00
  OriGene Technologies GmbH

CD70 (39-193, His-tag)
CD70 Human Purified > 80 % by SDS - PAGE E. coli
0.5 mg / $820.00
  OriGene Technologies GmbH

CD70 (39-193, His-tag)
CD70 Human Purified > 80 % by SDS - PAGE E. coli
0.1 mg / $320.00
  OriGene Technologies GmbH

CD70 (39-193, His-tag)
CD70 Human Purified > 90 % by SDS - PAGE
0.25 mg / $1,400.00
  OriGene Technologies GmbH

CD70 (39-193, His-tag)
CD70 Human Purified > 90 % by SDS - PAGE
50 µg / $400.00
  OriGene Technologies GmbH

Positive controls for CD70 (1 products)

Catalog No. Species Pres. Purity   Source  

CD70 overexpression lysate
CD70 overexpression lysate
0.1 mg / $295.00
  OriGene Technologies, Inc.

Recommended Secondary Antibodies for CD70 (11 products)

Catalog No. Host Clone/Iso. Pres.   React. Applications  

Mouse IgG (H+L chain) antibody
Mouse IgG (H+L chain) antibody Rabbit AP C, E, WB
    OriGene Technologies GmbH

Mouse IgG (H+L chain) antibody
Mouse IgG (H+L chain) antibody Rabbit Biotin C, E, WB
    OriGene Technologies GmbH

Mouse IgG (H+L chain) antibody
Mouse IgG (H+L chain) antibody Rabbit FITC E, ICC/IF
    OriGene Technologies GmbH

Mouse IgG (H+L chain) antibody
Mouse IgG (H+L chain) antibody Rabbit HRP C, E, WB
    OriGene Technologies GmbH

Mouse IgG (H+L chain) antibody
Mouse IgG (H+L chain) antibody Rabbit Texas Red ICC/IF
    OriGene Technologies GmbH

Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody Rabbit PE F
    OriGene Technologies GmbH

Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody Goat PE
    OriGene Technologies GmbH

Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody Donkey PE
    OriGene Technologies GmbH

Mouse IgG (H+L chain), adsorbed antibody
Mouse IgG (H+L chain), adsorbed antibody Goat Cy2
    OriGene Technologies GmbH

Mouse IgG (H+L chain), adsorbed antibody
Mouse IgG (H+L chain), adsorbed antibody Goat Cy3
    OriGene Technologies GmbH

Mouse IgG (H+L chain), adsorbed antibody
Mouse IgG (H+L chain), adsorbed antibody Goat Cy5
    OriGene Technologies GmbH
Click here to see all secondary antibodies for CD70
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