Product Description for CD70
CD70.
Presentation: Purified
Presentation: Purified
Properties for CD70
| Product Category | Proteins & Growth Factors |
|---|---|
| Target Category | |
| Quantity | 0.25 mg |
| Synonyms | CD27 ligand, CD27L, CD27LG, TNFSF7, Tumor necrosis factor ligand superfamily member 7 |
| Presentation | Purified |
| Molecular weight | 18.2 kDa |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Purity | > 90 % by SDS - PAGE |
| Background | CD70, also known as CD70 antigen, is a transmembrane protein in the TNF receptor superfamily. It functions as a co-stimulatory molecule that supports lymphocyte activation and survival. This protein binds to the transmembrane glycoprotein CD27 ligand/CD70 which is expressed on activated B cells, activated T cells, and dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T cell activation, and thus is proliferation of co-stimulated T cells, as well as the generation of cytolytic T cells. Recombint human CD70, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventiol chromatography techniques. |
| Concentration | 0.25 mg/ml (determined by absorbance at 280nm) |
| General Readings | Welten SP., et al. (2013) J. Virol. 87:6851-6865.Polak ME., et al. (2012) J. Invest. Dermatol. 132:1636-1644. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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