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CD21 antibody

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Principal name

CD21 antibody

Alternative names for CD21 antibody

Complement receptor type 2, CR2, C3DR, C3d receptor, EBV Receptor, Dendritic Cell Marker, Complement C3d receptor, Epstein-Barr virus receptor

SwissProt ID

P19070 (Mouse), P20023 (Human), Q5NT87 (Canfa), Q8HY44 (Bovin)

Gene ID

1380 (CR2)

Ncbi ID

9606, 9615, 9913, NP_001006659, NP_004235, NM_001877, NP_001868, NM_001006658

Available reactivities

Hu (Human), Bov (Bovine), Fe (Feline), Gt (Goat), Mink, Sh (Sheep), Can (Canine), Por (Porcine), Eq (Equine), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Functional assay (FN), Enzyme Immunoassay (E)

Selected product citations ‐ of AM08109RP-N

1. Rahe, MC;Murtaugh, MP. Interleukin-21 Drives Proliferation and Differentiation of Porcine Memory B Cells into Antibody Secreting Cells. PLoS ONE 2017, e0171171, 12, 1. PubMed PMID: 28125737.

Background of CD21 antibody

The CD21 antigen is expressed on mature B cells, follicular dendritic cells and pharyngeal and cervical epithelial cells [1,2]. CD21, also known as the Complement receptor type 2 (CR2) or Epstein-Barr virus (EBV) receptor, is a receptor for the C3 activation fragments iC3b and C3d. CD21 is part of a multimeric complex on B cells which includes CD19 and CD81 [3]. The ligand for CD21 is generated during activation of complement by the attachment of C3d to potential antigen. This creates fusion proteins that may cross-link the CD19-CD21-CD81 complex to sIg on antigen-specific B cells. The resulting signal transduction lowers the threshold for cellular activation. This enables an antibody reaction to natural protein antigens containing only one or a few epitopes and therefore unable to effectively cross-link Ig molecules on specific B cells. For example, keyhole limpet hemocyanin (KLH) immune complexes can be taken up and processed by all CR2-bearing B cells, regardless of their antigen specificity. KLH immune complexes taken up this way by non-specific B cells were shown to be presented to KLH-specific, MHC class II Th cells. CD23 may also serve as a ligand for CD21 [3].

General readings

1. Tedder T.F., L.T. Clement, and Cooper M.D.. Expression of C3d receptors during human B cell differentiation:
Immunofluorescence analysis with the HB-5 monoclonal antibody. J Immunol. 1984:133:678.
2. Denham, S., R.J. Zwart, J.T.D. Whittall, M. Pampusch, A.H. Corteyn, A.T.J. Bianchi, M.P. Murtaugh, R.M.E. Parkhouse, H.
Tlaskalova, J. Sinkora, M. Siinkora, and Z. Rehakova. 1998. Monoclonal antibodies putatively identifying porcine B cells.
Veter. Immunol. Immunopathol. 60:317-328.
3. Pescovitz, M. Personal communication.

DM028 - CD21
Formalin Fixed, Paraffin Embedded Human Tonsil stained with CD21 antibody DM028 / DM028-05
SM1785F - CD21
Staining of human peripheral blood lymphocytes with Mouse Anti Human CD21-FITC (SM1785F/FT).
SM1785P - CD21
Staining of human peripheral blood lymphocytes with Mouse Anti Human CD21 Antibody (Cat.-No SM1785P).
SM1785P - CD21
Immunofluorescence staining of human tonsil cryosection using Mouse anti Human CD1a antibody (Cat.No SM1858P), red in A and Mouse anti Human CD21 (Cat.-No SM1785P), green in B. C is the merged image with nuclei counterstained blue using DAPI. High power.
SM1785P - CD21
Immunoperoxidase staining of human tonsil cryosection using Mouse ati Human CD21 antibody (Cat.-No SM1785P) followed by HISTAR detection system. Medium power.
SM1785P - CD21
Immunofluorescence image of human tonsil cryosection stained with Sheep anti Human LOX-1 antibody (cat.-NO SP2139P) in red and with Mouse anti Human CD21 antibody (Cat.-No SM1785P) in red. Nuclei are stained blue using DAPI. Merged image on right.
SM1785P - CD21
Immunofluorescence staining of human tonsil cryosection with Mouse anti Human CD11b antibody, clone ICRF44 (), red in A and Mouse anti Human CD21 (Cat.-No SM1785P), green in B. C is the merged image with nuclei counterstained blue using DAPI. medium power.
SM1785P - CD21
Immunoperoxidase staining of human spleen cryosection using Mouse ati Human CD21 antibody (Cat.No SM1785P) followed by HISTAR detection system. Low power.
SM1785R - CD21
Staining of human peripheral blood lymphocytes with Mouse anti Human CD21-RPE (SM1785R/RT)
AM03064PU-N - CD21
Double staining of human, canine and porcine B lymphocytes with anti-CD79a (HM57) and anti-CD21 (LT21) antibody.
AM03064FC-N - CD21
Double staining of human, canine and porcine B lymphocytes with anti-CD79a (HM57) and anti-CD21 (LT21) antibody
AM03064RP-N - CD21
Double staining of human, canine and porcine B lymphocytes with anti-CD79a (HM57) and anti-CD21 (LT21) antibody
AM05866PU-N - CD21
Staining of canine peripheral blood lymphocytes with mouse anti canine CD21
AM05866RP-N - CD21
This antibody staining of canine peripheral blood lymphocytes
AP17240PU-N - CD21
Formalin-fixed and paraffin-embedded human Lymph reacted with CD21 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
AP17240PU-N - CD21
Flow Cytometry analysis of Ramos cells using CD21 Antibody (C-term) Cat.-No AP17240PU-N (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
AP17240PU-N - CD21
Western blot analysis of AP17240PU-N CD21 antibody (C-term) in Ramos cell line lysates (35 µg/lane). CR2 (arrow) was detected using the purified Pab.
AM31230AF-N - CD21
A typical staining pattern with the B-E5 monoclonal antibody of lymphocytes
AM31230PU-N - CD21
A typical staining pattern with the B-E5 monoclonal antibody of lymphocytes
AM31230FC-N - CD21
A typical staining pattern with the B-E5 monoclonal antibody of lymphocytes
AM31230RP-N - CD21
A typical staining pattern with the B-E5 monoclonal antibody of lymphocytes
DDX0120P-50 - CD21
mAb 7D6 staining on FDC clusters. Slides were incubated with mAb 7D6 and subsequently with a sheep anti-mouse IgG1. The binding of antibody was revealed using APAAP method and developed by Fast red substrate.
DDX0120P-50 - CD21
Giemsa staining of isolated FDCs clusters.
AM10060SU-N - CD21
Formalin-Fixed, Paraffin-Embedded Human tonsil stained with CD21 antibody Cat.-No. AM10060SU-N using peroxidase conjugate and DAB chromogen. Note the membrane staining of follicular dendritic cells and their network.
AM39015FC-N - CD21
Representative DataClone B-ly4 (CD21) was analyzed by flow cytometry using a blood sample obtained from a healthy volunteer. Direct staining was performed using 10 µl of the PE-conjugated monoclonal antibody and 100 µl of blood sample.
AM32268SU-N - CD21
Formalin-Fixed, Paraffin-Embedded Human Tonsil stained with CD21 antibody clone 2G9
AM05516PU-M - CD21
Staining of Bovine peripheral blood lymphocytes with CD21 Antibody Cat.-No AM05516PU-M (clone CC21)

AM33220PU-S - CD21
Human tonsil stained with anti-CD21 Antibody Cat.-No AM33220PU (Clone SP186).
AM33220PU-S - CD21
Western Blot analysis of Daudi cell lysate with anti-CD21 Antibody Cat.-No AM33220PU (Clone SP186).
AM33220PU-S - CD21
Flow Cytometric analysis of Rabbit anti-CD21 Antibody Cat.-No AM33220PU (Clone SP186) in Raji (green) compare to negative control of rabbit IgG (blue).
AM33228PU-S - CD21
Human tonsil stained with anti-CD21 Antibody Cat.-No AM33228PU (Clone SP199).
AM33228PU-S - CD21
Western Blot analysis of Daudi cell lysate with anti-CD21 Antibody Cat.-No AM33228PU (Clone SP199).
AM33228PU-S - CD21
Flow Cytometric analysis of Rabbit anti-CD21 Antibody Cat.-No AM33228PU (Clone SP199) in Raji (green) compare to negative control of rabbit IgG (blue).
CPA8346-50Assays - CD21
Flow cytometric analysis of human peripheral blood lymphocytes using Anti-CD21 Antibody-FITC labled.
CPA8418-50Assays - CD21
Flow cytometric analysis of human peripheral blood lymphocytes using Anti-CD21 Antibody-PE labled.
CPA8505-100ul - CD21
Flow cytometric analysis of human peripheral blood lymphocytes using Anti-CD21 Antibody; followed by anti-mouse IgG PE.
TP321379 - CD21
TA327627 - CD21
Immunohistochemistry staining of Paraffin Tonsil tissue by CD21 antibody (dilution: 1:25 - 1:100; visualization of staining: Membranous)
TA327628 - CD21
Immunohistochemistry staining of Paraffin Tonsil tissue by CD21 antibody (dilution: 1:50 - 1:200; visualization of staining: Membranous)
TA353673 - CR2
Western Blot analysis of Daudi cell lysate with anti-CD21 antibody.
TA353673 - CR2
Human tonsil stained with anti-CD21 antibody.
TA353673 - CR2
Flow cytometric analysis of rabbit anti-CD21 (SP199) antibody in Raji (green) compare to negative control of rabbit IgG (blue).
TA353673 - CR2
Human Reactive Lymph Node stained with anti-CD21 antibody.
TA353672 - CR2
Western Blot analysis of Daudi cell lysate with anti-CD21 antibody.
TA353672 - CR2
Human tonsil stained with anti-CD21 antibody.
TA353672 - CR2
Flow cytometric analysis of rabbit anti-CD21 (SP186) antibody in Raji (green) compare to negative control of rabbit IgG (blue).
TA353672 - CR2
Human Reactive Lymph Node stained with anti-CD21 antibody.
TA353672 - CR2
Human Spleen stained with anti-CD21 antibody.
TA353672 - CR2
Human Colon stained with anti-CD21 antibody.
TA350811 - CD21
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using (CR2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
TA350811 - CD21
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (CR2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD21 antibody
A typical staining pattern with the B-E5 monoclonal antibody of lymphocytes Mouse IgG2a B-E5 Purified Hu F, P
2ml (200T) / $320.00
  OriGene Technologies GmbH

CD21 antibody
A typical staining pattern with the B-E5 monoclonal antibody of lymphocytes Mouse IgG2a B-E5 PE Hu F
1ml (100T) / $390.00
  OriGene Technologies GmbH

CD21 antibody
CD21 Mouse IgG2a 4C5 Ig Fraction Hu C, ICC/IF
1 ml / $430.00
  OriGene Technologies GmbH

CD21 antibody
Formalin-Fixed, Paraffin-Embedded Human Tonsil stained with CD21 antibody clone 2G9 Mouse IgG2a 2G9 Supernatant Hu C, P
1 ml / $700.00
  OriGene Technologies GmbH

CD21 antibody
Representative Data Clone B-ly4 (CD21) was analyzed by flow cytometry using a blood sample obtained from a healthy volunteer. Direct staining was performed using 10 µl of the PE-conjugated monoclonal antibody and 100 µl of blood sample. Mouse IgG1 B-ly4 FITC Hu F
100 Tests / $400.00
  OriGene Technologies GmbH

CD21 antibody
Representative Data Clone B-ly4 (CD21) was analyzed by flow cytometry using a blood sample obtained from a healthy volunteer. Direct staining was performed using 10 µl of the PE-conjugated monoclonal antibody and 100 µl of blood sample. Mouse IgG1 B-ly4 Aff - Purified Hu C, F
1 ml / $270.00
  OriGene Technologies GmbH

CD21 antibody
Representative Data Clone B-ly4 (CD21) was analyzed by flow cytometry using a blood sample obtained from a healthy volunteer. Direct staining was performed using 10 µl of the PE-conjugated monoclonal antibody and 100 µl of blood sample. Mouse IgG1 B-ly4 PE Hu F
100 Tests / $470.00
  OriGene Technologies GmbH

CD21 (C-term) antibody
Formalin-fixed and paraffin-embedded human Lymph reacted with CD21 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu F, P, WB
0.4 ml / $415.00
  OriGene Technologies GmbH
+2 additional images

CD21 antibody
Formalin Fixed, Paraffin Embedded Human Tonsil stained with CD21 antibody DM028 / DM028-05 Mouse IgG1 1F8 Supernatant Hu P
1 ml / $620.00
  OriGene Technologies GmbH

CD21 antibody
Formalin Fixed, Paraffin Embedded Human Tonsil stained with CD21 antibody DM028 / DM028-05 Mouse IgG1 1F8 Supernatant Hu P
0.5 ml / $400.00
  OriGene Technologies GmbH

CD21 antibody
Staining of human peripheral blood lymphocytes with Mouse Anti Human CD21-FITC (SM1785F/FT). Mouse IgG1 LB21 FITC Hu F
0.1 mg / $400.00
  OriGene Technologies GmbH

CD21 antibody
Staining of human peripheral blood lymphocytes with Mouse Anti Human CD21-FITC (SM1785F/FT). Mouse IgG1 LB21 FITC Hu F
25 µg / $180.00
  OriGene Technologies GmbH

CD21 antibody
Staining of human peripheral blood lymphocytes with Mouse anti Human CD21-RPE (SM1785R/RT) Mouse IgG1 LB21 PE Hu F
100 Tests / $480.00
  OriGene Technologies GmbH

CD21 antibody
Staining of human peripheral blood lymphocytes with Mouse anti Human CD21-RPE (SM1785R/RT) Mouse IgG1 LB21 PE Hu F
25 Tests / $220.00
  OriGene Technologies GmbH

CD21 (CD21L) antibody
mAb 7D6 staining on FDC clusters. Slides were incubated with mAb 7D6 and subsequently with a sheep anti-mouse IgG1. The binding of antibody was revealed using APAAP method and developed by Fast red substrate. Mouse IgG1 7D6 Purified Hu C
0.1 mg / $440.00
  Dendritics SAS
+1 additional image

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CD21 (transcript variant 2)
  Recombinant protein of human complement component (3d/Epstein Barr virus) receptor 2 (CR2), transcript variant 2  
CD21 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.		 HEK293 cells
20 µg / $788.00
  OriGene Technologies, Inc.
 

ELISA Kits

Catalog No.    

Human CD21/CR2 ELISA Kit
Human CD21/CR2 ELISA Kit  
1 kit / $500.00
  OriGene Technologies, Inc.

Human CD21 ELISA Kit
Human CD21 ELISA Kit  
1 kit / $250.00
  OriGene Technologies, Inc.

Human CD21 ELISA Kit
Human CD21 ELISA Kit  
1 kit / $425.00
  OriGene Technologies, Inc.

Human CD21 ELISA Kit
Human CD21 ELISA Kit  
1 kit / $645.00
  OriGene Technologies, Inc.

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