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DM127P Cytokeratin 17 antibody

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0.1 mg / $370.00
Delivery Time: 10 working days*
(*) valid for US customers only

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Mouse anti Human, Rat Cytokeratin 17 Ks17.E3

DM127P

Product Description for Cytokeratin 17

Mouse anti Human, Rat Cytokeratin 17 Ks17.E3.
Presentation: Purified
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot, Flow Cytometry, Paraffin Sections.

Properties for Cytokeratin 17

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms CK17, Cytokeratin-17, K17, KRT17, Keratin 17, Keratin type I cytoskeletal 17, Keratin-17
Presentation Purified
Reactivity Hu, Rt
Applications C, F, ICC/IF, P, WB
Clonality Monoclonal
Clone Ks17.E3
Host Mouse
Isotype IgG2b
Molecular weight 46 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q04695
Immunogen:
A cytoskeletal preparation from Rat colon.
GeneID:
3872
Isotype control AM03110PU-N, SM12P
Application Immunoblotting: 1/100-1/1000.
Immunocytochemistry.
Immunohistochemistry on Frozen and Paraffin Embedded tissues: 1/25-1/200 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complec (ABC) as detection regant.
Flow Cytometry: 1/25-1/200.
Background Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium.
Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immuno-histochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
Concentration 1.0 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Poschmann G, Sitek B, Sipos B, Ulrich A, Wiese S, Stephan C, et al. Identification of proteomic differences between squamous cell carcinoma of the lung and bronchial epithelium. Mol Cell Proteomics. 2009 May;8(5):1105-16. doi: 10.1074/mcp.M800422-MCP200. Epub 2009 Jan 27. PubMed PMID: 19176476. (Free PMC Article available, 6 images available)
General Readings
  1. Guelstein VI, Tchypysheva TA, Ermilova VD, Litvinova LV, Troyanovsky SM, Bannikov GA. Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer. Int J Cancer. 1988 Aug 15;42(2):147-53. PubMed PMID: 2456993.
  2. Troyanovsky SM, Guelstein VI, Tchipysheva TA, Krutovskikh VA, Bannikov GA. Patterns of expression of keratin 17 in human epithelia: dependency on cell position. J Cell Sci. 1989 Jul;93 ( Pt 3):419-26. PubMed PMID: 2481679.
  3. Smedts, F., Ramaekers, F., Troyanovsky, S., Pruszczynski, M., Link, M., Lane, B., Leigh, I., and Vooijs, P. (1990). Keratin expression in cervical cancer, Am J Pathol 141, 497-511.
  4. Wetzels RH, Kuijpers HJ, Lane EB, Leigh IM, Troyanovsky SM, Holland R, et al. Basal cell-specific and hyperproliferation-related keratins in human breast cancer. Am J Pathol. 1991 Mar;138(3):751-63. PubMed PMID: 1705754. (Free PMC Article available)
  5. Wetzels RH, Schaafsma HE, Leigh IM, Lane EB, Troyanovsky SM, Wagenaar SS, et al. Laminin and type VII collagen distribution in different types of human lung carcinoma: correlation with expression of keratins 14, 16, 17 and 18. Histopathology. 1992 Apr;20(4):295-303. PubMed PMID: 1374358.
  6. Smedts F, Ramaekers F, Troyanovsky S, Pruszczynski M, Robben H, Lane B, et al. Basal-cell keratins in cervical reserve cells and a comparison to their expression in cervical intraepithelial neoplasia. Am J Pathol. 1992 Mar;140(3):601-12. PubMed PMID: 1372156. (Free PMC Article available)
  7. Smedts F, Ramaekers F, Link M, Lauerova L, Troyanovsky S, Schijf C, et al. Detection of keratin subtypes in routinely processed cervical tissue: implications for tumour classification and the study of cervix cancer aetiology. Virchows Arch. 1994;425(2):145-55. PubMed PMID: 7524976.
  8. Litvinov SV, van Driel W, van Rhijn CM, Bakker HA, van Krieken H, Fleuren GJ, et al. Expression of Ep-CAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation. Am J Pathol. 1996 Mar;148(3):865-75. PubMed PMID: 8774141. (Free PMC Article available)
  9. Moll, R., et al. (1995). Differenzierungsmarker bei gynäkologischen Tumoren: Methodische und diagnostische Aspekte. In: Aktuelle Aspekte der Tumorimmunologie in der Gynäkologie. W Zuckschwerdt Verlag.
  10. Demirkesen C, Hoede N, Moll R. Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins. J Cutan Pathol. 1995 Dec;22(6):518-35. PubMed PMID: 8835171.
  11. de Jong EM, van Vlijmen IM, van Erp PE, Ramaekers FC, Troyanovski SM, van de Kerkhof PC. Keratin 17: a useful marker in anti-psoriatic therapies. Arch Dermatol Res. 1991;283(7):480-2. PubMed PMID: 1724898.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Buffer System:
PBS
Preservatives:
0.09% Sodium Azide
State:
Liquid purified IgG fraction
Purified
Species Reactivity
Species reactivity (tested):
Human, Rat.
Specificity
Specificity:
Clone E3 reacts with Cytokeratin 17 in basal layers of pseudo-stratified and transitional epithelia.
Gene ID 3872

Accessory Products

Proteins and/or Positive Controls

Proteins for Cytokeratin 17 (2 products)

Catalog No. Species Pres. Purity   Source  

Cytokeratin 17 (1-432, His-tag)
Cytokeratin 17 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / $1,070.00
  OriGene Technologies GmbH

Cytokeratin 17 (1-432, His-tag)
Cytokeratin 17 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / $400.00
  OriGene Technologies GmbH

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