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AM09336PU-N Hepatitis B Surface Antigen / HBsAg antibody

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1 ml / $360.00
Delivery Time: 10 working days*
(*) valid for US customers only

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Mouse anti Hepatitis B Surface Antigen / HBsAg P3G9A8

AM09336PU-N

Product Description for Hepatitis B Surface Antigen / HBsAg

Mouse anti Hepatitis B Surface Antigen / HBsAg P3G9A8.
Presentation: Liquid
Product is tested for Paraffin Sections.

Properties for Hepatitis B Surface Antigen / HBsAg

Product Category Primary Antibodies
Quantity 1 ml
Synonyms HBV surface antigen, Hepatitis B Virus
Presentation Liquid
Applications P
Clonality Monoclonal
Clone P3G9A8
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Purified Hepatitis B surface antigen.
Add. information The volume is sufficient for at least 100 immunohistochemical tests (100 µl working solution/test).
Application Immunohistochemistry on Paraffin Sections: 1/10-1/25 (No protease pre-treatment).
Blocking of endogenous Peroxidase with 1% Peroxide in Methanol is recommended.
Positive Control: HBV infected liver.
Incubation Time: 60 min at RT or 2-8°C overnight.
Background Hepatitis B Virus (HBV) infection induces a disease state characterised by liver damage, inflammation and viral persistence. Infection also increases the risk of hepatocellular carcinoma. HBV belongs to the Hepadnaviridae family of viruses. Its genome consists of partially double stranded circular DNA. The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. The HBV genome also encodes a DNA polymerase that also acts as a reverse transcriptase.
Hepatitis B infection is normally diagnosed from serological tests that detect HBsAg but as the disease progresses this antigen may no longer be present in the blood and tests for HBcAg are used. If HBsAg can be detected in the blood for longer than six months, chronic hepatitis B is diagnosed.
The antigenic determinant of the protein moiety of the HBsAg determines specific characteristics of different serotypes and provides the basis of immunodetection. HBsAg has antigenic heterogeneity, specifically, two pairs of sub specific determinants, d/y and w/r allow the following combinations: adw, ayw, adr, ayr.
General Readings
  1. Beasley R.P., et al. (1981) Hepatocellular carcinoma and hepatitis B virus: a prospective study of 22,707 men in Taiwan. Lancet ii; 1129
  2. Hoofnagel J.H., and Alter H.J. (1984) Chronic viral hepatitis. In: Vyas G.N. et al. Eds. Viral hepatitis and liver disease. Grune & Stratton, N.Y. pp 97 ff.
  3. Swensen P.D. et al. (1988). Antigenic analysis of HBsAg with monoclonal antibodies specific for S protein and pre-S2. Viral hepatitis and liver disease. Alan R. Liess, Inc. pp. 627ff.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Buffer System:
PBS, pH 7.3
Preservatives:
0.09% Sodium Azide
State:
Liquid Concentrated Ig fraction.
Liquid
Specificity
Specificity:
This antibody recognizes the Ad and Ay subtype of the Hepatitis B virus surface antigen. 
The antibody to HBsAG is used for the detection of this antigen in liver cells, which are infected by hepatitis B virus. In healthy liver and other tissues staining is negative.
Species:
Hepatitis B Virus.

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