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TA327946 MMP-1 antibody

Mouse Monoclonal anti-MMP1 Antibody

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Search for all "MMP-1"

0.1 mg / $230.00
Delivery Time: 5-7 working days*
(*) valid for US customers only

View Datasheet

Quick Overview

Mouse anti Human MMP-1 F15P3B6

TA327946

Product Description for MMP-1

Mouse anti Human MMP-1 F15P3B6.
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for MMP-1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms CLG, Fibroblast collagenase, Interstitial collagenase, MMP1, Matrix metalloproteinase-1
Presentation Aff - Purified
Reactivity Hu
Applications P, WB
Clonality Monoclonal
Clone F15P3B6
Host Mouse
Isotype IgG1
Molecular weight ~54 kDa
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P03956
Immunogen:
Ovalbumin-conjugated synthetic peptide CSSFGFPRTVKH
GeneID:
4312
Application Western Blot: Use 4 µg/ml antibody dilution buffer for each mini-gel. 
Immunohistochemistry on Paraffin Sections.
Background Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade substances withinthe extracellular matrix. The MMP family includes six different groups of enzymes: collagenases, gelatinases, stromelysins, transmembrane MMPs, matrilysins and others. MMPs are secreted as proenzymes that have to be cleaved in order to be activated. Other MMPs, plasmins as well as other factors activate MMPs. MMPs are thought to play an important role in tissue remodeling associated with various physiological and pathological processes. MMP1 cleaves collagens of types I, II, III, VII and X.MMP1 is thought to play an important role in rheumatoid and osteo-arthritis pathogenesis as mediators of cartilage and bone destruction.
Structure: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains, predicted molecular weight approximately 54 kD.
Distribution: Extracellular. 
Function: MMP1 cleaves collagens of types I, II, III, VII and X. MMP-1 is thought to play an important role in rheumatoid and osteo-arthritis pathogenesis as mediators of cartilage and bone destruction.
Interaction: MCP1, MCP3, MCP4, TIMP-1, MMP7, Collagen type II α1, IBP-3, Integrin α2, CD44, CD147, Brevican, Chymase 1, Aggrecan 1.
Concentration 0.5 mg/ml
General Readings
  1. Murray GI, Duncan ME, Arbuckle E, Melvin WT, Fothergill JE. Matrix metalloproteinases and their inhibitors in gastric cancer. Gut. 1998 Dec;43(6):791-7. PubMed PMID: 9824606. (Free PMC Article available, 5 images available)
  2. Murray GI, Duncan ME, O'Neil P, McKay JA, Melvin WT, Fothergill JE. Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. J Pathol. 1998 Jul;185(3):256-61. PubMed PMID: 9771478.
  3. Boire A, Covic L, Agarwal A, Jacques S, Sherifi S, Kuliopulos A. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell. 2005 Feb 11;120(3):303-13. PubMed PMID: 15707890.
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Shelf life: one year from despatch.
Format
Purification:
Immunoaffinity Chromatography
Buffer System:
PBS, pH 7.2
Preservatives:
0.09% Sodium Azide
State:
Liquid purified IgG fraction
Aff - Purified
Species Reactivity
Species reactivity (expected):
Gorilla, Gibbon, Monkey, Mouse.
Species reactivity (tested):
Human.
Specificity
Specificity:
This antibody detects Human MMP1. Other species not tested.

Accessory Products

Proteins and/or Positive Controls

Proteins for MMP-1 (10 products)

Catalog No. Species Pres. Purity   Source  

MMP-1 (transcript variant 1)
MMP-1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. 		HEK293 cells
20 µg / $748.00
  OriGene Technologies, Inc.

MMP-1 (transcript variant 1)
MMP-1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining. 		HEK293 cells
10 µg / $299.00
  OriGene Technologies, Inc.

MMP-1 (transcript variant 1)
MMP-1 Human > 90 %
Preparation: .
Purity Detail: >90% as determined by SDS-PAGE and Coomassie blue staining. 		E. coli
10 µg / $230.00
  OriGene Technologies, Inc.

MMP-1 (transcript variant 1)
MMP-1 Human > 90 %
Preparation: .
Purity Detail: >90%, as determined by Coomassie stained SDS-PAGE. 		HEK293 cells
10 µg / $260.00
  OriGene Technologies, Inc.

MMP-1 (N-term HIS tag, transcript variant 1)
MMP-1 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. 		E. coli
50 µg / $205.00
  OriGene Technologies, Inc.

MMP-1
MMP-1 Human > 90 % pure by SDS-PAGE and HPLC analyses. E. coli
  OriGene Technologies GmbH

MMP-1
MMP-1 Human > 90 % pure by SDS-PAGE and HPLC analyses. E. coli
  OriGene Technologies GmbH

MMP-1 (100-469, His-tag)
MMP-1 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / $820.00
  OriGene Technologies GmbH

MMP-1 (100-469, His-tag)
MMP-1 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / $320.00
  OriGene Technologies GmbH

MMP-1 (Pro)
MMP-1 Human > 98 % >95% by SDS-PAGE, essentially free of contaminating MMPs or TIMPs. Chondrocytes
  OriGene Technologies GmbH

Recommended Secondary Antibodies for MMP-1 (11 products)

Catalog No. Host Clone/Iso. Pres.   React. Applications  

Mouse IgG (H+L chain) antibody
Mouse IgG (H+L chain) antibody Rabbit AP C, E, WB
    OriGene Technologies GmbH

Mouse IgG (H+L chain) antibody
Mouse IgG (H+L chain) antibody Rabbit Biotin C, E, WB
    OriGene Technologies GmbH

Mouse IgG (H+L chain) antibody
Mouse IgG (H+L chain) antibody Rabbit FITC E, ICC/IF
    OriGene Technologies GmbH

Mouse IgG (H+L chain) antibody
Mouse IgG (H+L chain) antibody Rabbit HRP C, E, WB
    OriGene Technologies GmbH

Mouse IgG (H+L chain) antibody
Mouse IgG (H+L chain) antibody Rabbit Texas Red ICC/IF
    OriGene Technologies GmbH

Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody Rabbit PE F
    OriGene Technologies GmbH

Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody Goat PE
    OriGene Technologies GmbH

Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody Donkey PE
    OriGene Technologies GmbH

Mouse IgG (H+L chain), adsorbed antibody
Mouse IgG (H+L chain), adsorbed antibody Goat Cy2
    OriGene Technologies GmbH

Mouse IgG (H+L chain), adsorbed antibody
Mouse IgG (H+L chain), adsorbed antibody Goat Cy3
    OriGene Technologies GmbH

Mouse IgG (H+L chain), adsorbed antibody
Mouse IgG (H+L chain), adsorbed antibody Goat Cy5
    OriGene Technologies GmbH
Click here to see all secondary antibodies for MMP-1
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