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SM1376B Complement factor I antibody

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0.1 mg / $250.00
Delivery Time: 5-7 working days*
(*) valid for US customers only

View Datasheet

Quick Overview

Mouse anti Human Complement factor I OX-21

SM1376B

Product Description for Complement factor I

Mouse anti Human Complement factor I OX-21.
Presentation: Biotin
Product is tested for Enzyme Immunoassay, Immunoprecipitation, Radioimmunoassay, Western blot / Immunoblot, Flow Cytometry.

Properties for Complement factor I

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms AHUS3, C3B/C4B inactivator, C3BINA, C3b-INA, CFI, IF, KAF
Presentation Biotin
Reactivity Hu
Applications E, F, IP, R, WB
Clonality Monoclonal
Clone OX-21
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P05156
Immunogen:
Human complement Factor I.
Donor: Immunized FI cross DBA/2 x BALB/c mouse spleen cells
Fusion Partner: NS-1 mouse myeloma
GeneID:
3426
Isotype control SM10B (for use in human samples)
Application ELISA: 1/40000 (Plates were coated with 2 ug/ml purified Factor I, and HRPO-Streptavidin was used for detection). 
Western Blot.
Flow Cytometry.
Immunoprecipitation.
Radioimmunoassay.
Background Factor I is a serine protease with a high degree of specificity for C3b and C4b. It requires protein cofactors for cleavage of these complement protein breakdown products: Factor H, CR1 and MCP are required for C3b cleavage and C4bp or CR1 for C4b cleavage.
Concentration 0.1 mg/ml
General Readings
  1. Hsiung L, Barclay AN, Brandon MR, Sim E, Porter RR. Purification of human C3b inactivator by monoclonal-antibody affinity chromatography. Biochem J. 1982 Apr 1;203(1):293-8. PubMed PMID: 7103942. (Free PMC Article available)
  2. Kraus E, James W, Barclay AN. Cutting edge: novel RNA ligands able to bind CD4 antigen and inhibit CD4+ T lymphocyte function. J Immunol. 1998 Jun 1;160(11):5209-12. PubMed PMID: 9605115.
  3. Sedgwick JD, Ford AL, Foulcher E, Airriess R. Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts. J Immunol. 1998 Jun 1;160(11):5320-30. PubMed PMID: 9605131.
  4. Seddon B, Mason D. Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytes. J Exp Med. 1999 Jan 18;189(2):279-88. PubMed PMID: 9892610. (Free PMC Article available, 6 images available)
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Label:
Biotin
Buffer System:
PBS
Preservatives:
0.02% Sodium Azide
Stabilizers:
EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml
State:
Liquid purified IgG fraction
Specificity
Specificity:
Anti-human factor I (C3b inactivator) monoclonal antibody clone OX-21 recognizes human complement protein factor I.
Factor I has two polypeptide chains, 56kD and 38kD. This antibody detects only the 56kD chain.
This clone has been reported not to cross react with Rat.
Species:
Human.
Gene ID 3426

Accessory Products

Proteins and/or Positive Controls

Proteins for Complement factor I (1 products)

Catalog No. Species Pres. Purity   Source  

Complement factor I
Complement factor I Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. 		HEK293 cells
20 µg / $748.00
  OriGene Technologies, Inc.

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