AM26259PU-N Complement C5 antibody

Swiss Prot Num:

P01031

Immunogen:

Human C5

GeneID:

727

1. Klos A, Ihrig V, Messner M, Grabbe J, Bitter-Suermann D. Detection of native human complement components C3 and C5 and their primary activation peptides C3a and C5a (anaphylatoxic peptides) by ELISAs with monoclonal antibodies. J Immunol Methods. 1988 Jul 22;111(2):241-52. PubMed PMID: 3260926.
2. Kola A, Baensch M, Bautsch W, Hennecke M, Klos A, Casaretto M, et al. Epitope mapping of a C5a neutralizing mAb using a combined approach of phage display, synthetic peptides and site-directed mutagenesis. Immunotechnology. 1996 Jun;2(2):115-26. PubMed PMID: 9373320.
3. Kola A, Baensch M, Bautsch W, Klos A, Köhl J. Analysis of the C5a anaphylatoxin core domain using a C5a phage library selected on differentiated U937 cells. Mol Immunol. 1999 Feb;36(2):145-52. PubMed PMID: 10378686.

Store at 2 - 8 °C.
Shelf life: one year from despatch.

Purification:

Protein G

Buffer System:

PBS

Preservatives:

0.02% sodium azide

Stabilizers:

0.1% bovine serum albumin

State:

Liquid 0.2 µm filtered Ig fraction
Purified

Species reactivity (tested):

Human

Specificity:

The monoclonal antibody 557 recognizes an epitope of complement factor 5 (C5) and C5a. It is capable to inhibit the binding of C5a to the C5a receptor through a competitive mechanism, it does not block the cleavage of C5 into C5a and C5b.