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BP369HRP Complement C3c antibody

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1 ml / $390.00
Delivery Time: 3-5 working days*
(*) valid for US customers only

View Datasheet

Quick Overview

Sheep anti Human Complement C3c

BP369HRP

Product Description for Complement C3c

Sheep anti Human Complement C3c.
Presentation: HRP
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for Complement C3c

Product Category Primary Antibodies
Target Category
Quantity 1 ml
Synonyms C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, CPAMD1, Complement component 3
Presentation HRP
Reactivity Hu
Applications E, WB
Clonality Polyclonal
Host Sheep
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P01024
Immunogen:
Complement 3c.
GeneID:
718
Application Suitable for ELISA (1/200-1/800) and Western blotting (1/500-1/2000).
Background C3 plays a central role in the activation of the complement system. Processing of C3 by C3 convertase is the central reaction in both classical and alternative complement pathways, resulting in C3a and C3b. C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates, and help to initiate the complement cascade, potentially resulting in cellular apoptosis. C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c and C3dg. Defects in C3 can result in susceptibility to pyogenic infection.
Caution Do Not Use Sodium Azide as preservative.
Concentration 1.0 mg/ml
General Readings
  1. Janssen BJ, Huizinga EG, Raaijmakers HC, Roos A, Daha MR, Nilsson-Ekdahl K, et al. Structures of complement component C3 provide insights into the function and evolution of immunity. Nature. 2005 Sep 22;437(7058):505-11. PubMed PMID: 16177781.
Storage Store the antibody (undiluted) at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Should this product contain a precipitate we recommend microcentrifugation before use. Shelf life: One year from despatch.
Format
Label:
HRP
Purification:
Affinity chromatography on Protein G.
Buffer System:
PBS, pH 7.2, containing 0.01% Thiomersal as preservative.
State:
Liquid purified IgG fraction.
Specificity
Specificity:
This antibody detects Complement 3c, a polypeptide fragment which is present in C3.
Species:
Human.
Gene ID 718

Accessory Products

Proteins and/or Positive Controls

Proteins for Complement C3c (5 products)

Catalog No. Species Pres. Purity   Source  

Complement C3
Complement C3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. 		HEK293 cells
20 µg / $788.00
  OriGene Technologies, Inc.

Complement C3
Complement C3 Human Purified > 96 % pure by SDS-PAGE
Analysis: Cellulose acetate electrophoresis shows one band only with beta-2 electrophoretic mobility. Quantitative and qualitative analysis by radial immunodiffusion. 		Plasma
  OriGene Technologies GmbH

Complement C3
Complement C3 Human > 99 % Serum
  BBI Solutions

Complement C3
Complement C3 Human > 96 % Serum
  BBI Solutions

Complement C3b
Complement C3b Human Purified > 90 % by SDS-PAGE Serum
0.1 mg / $720.00
  OriGene Technologies GmbH

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Click here to see all secondary antibodies for Complement C3c
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