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SM1783LE CD2 antibody

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0.5 mg / $720.00
Delivery Time: 3-5 working days*
(*) valid for US customers only

View Datasheet

Quick Overview

Mouse anti Chimpanzee, Human, Monkey CD2 LT2

SM1783LE

Product Description for CD2

Mouse anti Chimpanzee, Human, Monkey CD2 LT2.
Presentation: Azide Free
Product is tested for Frozen Sections, Functional assay, Immunoprecipitation, Flow Cytometry.

Properties for CD2

Product Category Primary Antibodies
Target Category
Quantity 0.5 mg
Synonyms Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, SRBC, T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5
Presentation Azide Free
Reactivity Chimp, Hu, Mky
Applications C, F, FN, IP
Clonality Monoclonal
Clone LT2
Host Mouse
Isotype IgG2b
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P06729
Immunogen:
Normal Human peripheral blood lymphocytes.
Spleen cells from immunised BALB/c mice were fused with cells of the mouse X63.653 myeloma cell line.
GeneID:
914
Isotype control SM12A
Add. information Does not work on paraffin sections.
Application Flow Cytometry: Use 10 μl of 1/50-1/100 diluted antibody to label 106 cells in 100 μl.
Immunoprecipitation.
Functional Studies.
Immunohistochemistry on Frozen Sections: 1/200-1/400. 
The epitope recognized by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. We recommend the use of Acetone fixation for frozen sections.
Recommended Positive Control: Human Tonsil.
Background CD2 which is also known as E-rosette receptor, T11 and lymphocyte-function antigen-2 (LFA-2) is expressed on T cells, thymocytes, and subset of natural killer cells. Human CD2 functions as the receptor for sheep erythrocytes, human CD58 (LFA-3), and CD15s (Sialyl Lewis X). p56lck, p59fyn, CD3eta and CD3epsilon are tyrosine-phosphorylated after CD2 stimulation. CD2 play a role in T cell activation, T- or NK-cell-mediated cytolysis, apoptosis in activated peripheral T cells, and regulation of T cell anergy.
Concentration 1.0 mg/ml
General Readings
  1. Moingeon P, Chang HC, Sayre PH, Clayton LK, Alcover A, Gardner P, et al. The structural biology of CD2. Immunol Rev. 1989 Oct;111:111-44. PubMed PMID: 2576417.
  2. Beyers AD, Barclay AN, Law DA, He Q, Williams AF. Activation of T lymphocytes via monoclonal antibodies against rat cell surface antigens with particular reference to CD2 antigen. Immunol Rev. 1989 Oct;111:59-77. PubMed PMID: 2576418.
  3. Lin CW, Liu TY, Chen SU, Wang KT, Medeiros LJ, Hsu SM. CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features. Blood. 2005 Nov 15;106(10):3567-74. Epub 2005 Jul 26. PubMed PMID: 16046525.
  4. Kap YS, van Meurs M, van Driel N, Koopman G, Melief MJ, Brok HP, et al. A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. J Histochem Cytochem. 2009 Dec;57(12):1159-67. doi: 10.1369/jhc.2009.954123. Epub 2009 Sep 3. PubMed PMID: 19729671. (Free PMC Article available, 1 images available)
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity Chromatography on Protein G
Buffer System:
PBS, pH 7.4
Preservatives:
None
Stabilizers:
None
Endotoxin level:
< 0.01 EU/µg
State:
Liquid purified IgG fraction (Low Endotoxin)
Azide Free
Species Reactivity
Species reactivity (tested):
Human, Chimpanzee, Cynomolgus Monkey, Rhesus Monkey.
Specificity
Specificity:
SM1783LE is a single chain transmembrane glycoprotein of 50kD, expressed by T cells, NK cells and thymocytes. CD2 is a receptor for CD58 (LFA-3), and is important in mediating the interaction between T cells and target cells or antigen presenting cells.
This antibody inhibits NK cell mediated cytotoxicity, and ConA and PHA mediated blast transformation.

Accessory Products

Proteins and/or Positive Controls

Proteins for CD2 (8 products)

Catalog No. Species Pres. Purity   Source  

CD2
CD2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. 		HEK293 cells
20 µg / $748.00
  OriGene Technologies, Inc.

CD2 (C-term DDK/His tag)
CD2 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. 		HEK293 cells
20 µg / $748.00
  OriGene Technologies, Inc.

CD2
CD2 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining. 		HEK293 cells
10 µg / $299.00
  OriGene Technologies, Inc.

CD2
CD2 Human Purified E. coli
  OriGene Technologies GmbH

CD2
CD2 Human Purified E. coli
  OriGene Technologies GmbH

CD2
CD2 Human Purified E. coli
  OriGene Technologies GmbH

CD2 (25-209, His-tag)
CD2 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / $820.00
  OriGene Technologies GmbH

CD2 (25-209, His-tag)
CD2 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / $320.00
  OriGene Technologies GmbH

Recommended Secondary Antibodies for CD2 (11 products)

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Mouse IgG (H+L chain) antibody
Mouse IgG (H+L chain) antibody Rabbit HRP C, E, WB
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Mouse IgG (H+L chain) antibody
Mouse IgG (H+L chain) antibody Rabbit Texas Red ICC/IF
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Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody Rabbit PE F
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Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody Goat PE
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Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody Donkey PE
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Mouse IgG (H+L chain), adsorbed antibody
Mouse IgG (H+L chain), adsorbed antibody Goat Cy2
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Mouse IgG (H+L chain), adsorbed antibody
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Mouse IgG (H+L chain), adsorbed antibody
Mouse IgG (H+L chain), adsorbed antibody Goat Cy5
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Click here to see all secondary antibodies for CD2
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