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SM262LE CD11b antibody

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0.5 mg / $720.00
Delivery Time: 3-5 working days*
(*) valid for US customers only

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Quick Overview

Mouse anti Rat CD11b OX-42

SM262LE

Product Description for CD11b

Mouse anti Rat CD11b OX-42.
Presentation: Low Endotoxin
Product is tested for Frozen Sections, Immunoprecipitation, Flow Cytometry.

Properties for CD11b

Product Category Primary Antibodies
Target Category
Quantity 0.5 mg
Synonyms CD11 antigen-like family member B, CR-3 alpha chain, CR3A, Cell surface glycoprotein MAC-1 subunit alpha, ITGAM, Integrin alpha-M, Leukocyte adhesion receptor MO1, MAC1, Neutrophil adherence receptor
Presentation Low Endotoxin
Reactivity Rt
Applications C, F, IP
Clonality Monoclonal
Clone OX-42
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q63001
Immunogen:
Rat peritoneal macrophages. Spleen cells from immunised BALB/c mice were fused with cells of the NSO/U mouse myeloma cell line.
Add. information Endotoxin Level: less than 0.01 EU/µg
Application Immunoprecipitation.
Immunohistochemistry on frozen sections: 1/50 - 1/100; Clone MRC OX-42 has been reported as being suitable for use on paraffin-embedded material following PLP fixation (periodate-lysine-paraformaldehyde).
Flow Cytometry: 1/50 - 1/100; Use 10ul of the suggested working dilution to label 10e6 cells or 100µl whole blood.
Background The antigen is expressed on most macrophages, including resident and activated peritoneal macrophages and Kupffer cells and around 35% of alveolar macrophages. The antibody also labels dendritic cells, granulocytes and microglial cells in the brain.
Concentration 1.0 mg/ml
General Readings
  1. Robinson, A.P. et al. (1986) Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognising complement receptor type 3. Immunology. 57(2): 239 - 247.
  2. Barclay AN. The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues. Immunology. 1981 Apr;42(4):593-600. PubMed PMID: 7016746. (Free PMC Article available)
  3. Milligan CE, Cunningham TJ, Levitt P. Differential immunochemical markers reveal the normal distribution of brain macrophages and microglia in the developing rat brain. J Comp Neurol. 1991 Dec 1;314(1):125-35. PubMed PMID: 1797868.
  4. Whiteland JL, Nicholls SM, Shimeld C, Easty DL, Williams NA, Hill TJ. Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies. J Histochem Cytochem. 1995 Mar;43(3):313-20. PubMed PMID: 7868861.
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography on Protein G
Buffer System:
PBS, pH 7.2
State:
Liquid purified IgG
Low Endotoxin
Specificity
Specificity:
This antibdoy recognises the equivalent of human CD11b, the receptor for the iC3b component of complement. Functionally, clone OX-42 inhibits complement mediated rosettes.
Species:
Rat.

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