Product Description for Alpha-crystallin A chain / CRYA1
Mouse anti Human Alpha-crystallin A chain / CRYA1 OTIC3.
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.
Properties for Alpha-crystallin A chain / CRYA1
| Product Category | Primary Antibodies |
|---|---|
| Target Category | |
| Quantity | 0.1 ml |
| Synonyms | CRYAA, HSPB4, Heat shock protein beta-4 |
| Presentation | Purified |
| Reactivity | Hu |
| Applications | P, WB |
| Clonality | Monoclonal |
| Clone | OTIC3 |
| Host | Mouse |
| Isotype | IgG2b |
| Shipping to | Europe, USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies, Inc. |
Datasheet Extract
| Immunogen |
|
|---|---|
| Isotype control | AM03110PU-N, SM12P |
| Application | WB 1:2000 IHC 1:150 |
| Background | Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-termil extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not reture proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translatiol modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additiol functions of alpha crystallins are an autokise activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal domint congenital cataract (ADCC). [provided by RefSeq, Jul 2008]. |
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Accessory Products
Proteins and/or Positive Controls
Proteins for Alpha-crystallin A chain / CRYA1 (3 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| TP316946 |
Alpha-crystallin A chain / CRYA1 |
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|
Human |
> 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
$748.00
|
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| OriGene Technologies, Inc. | |||||||
| SA6018 |
Alpha-crystallin A chain / CRYA1 |
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|
Human | Purified | ≥ 95 by SDS-PAGE | E. coli |
0.1 mg /
$240.00
|
||
| OriGene Technologies GmbH | |||||||
| SA6018X |
Alpha-crystallin A chain / CRYA1 |
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|
|
Human | Purified | > 95 % by SDS-PAGE | E. coli |
1 mg /
$570.00
|
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| OriGene Technologies GmbH | |||||||
Positive controls for Alpha-crystallin A chain / CRYA1 (1 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| LY424743 |
CRYAA overexpression lysate |
||||||
 |
0.1 mg /
$295.00
|
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| OriGene Technologies, Inc. | |||||||
Recommended Secondary Antibodies for Alpha-crystallin A chain / CRYA1 (11 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1253AP |
Mouse IgG (H+L chain) antibody |
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|
|
Rabbit | AP | C, E, WB | ||||
| OriGene Technologies GmbH | |||||||
| R1253B |
Mouse IgG (H+L chain) antibody |
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|
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Rabbit | Biotin | C, E, WB | ||||
| OriGene Technologies GmbH | |||||||
| R1253F |
Mouse IgG (H+L chain) antibody |
||||||
|
|
Rabbit | FITC | E, ICC/IF | ||||
| OriGene Technologies GmbH | |||||||
| R1253HRP |
Mouse IgG (H+L chain) antibody |
||||||
|
Rabbit | HRP | C, E, WB | ||||
| OriGene Technologies GmbH | |||||||
| R1253TR |
Mouse IgG (H+L chain) antibody |
||||||
|
|
Rabbit | Texas Red | ICC/IF | ||||
| OriGene Technologies GmbH | |||||||
| R1403R |
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody |
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|
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Rabbit | PE | F | ||||
| OriGene Technologies GmbH | |||||||
| R1405R |
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody |
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|
|
Goat | PE | |||||
| OriGene Technologies GmbH | |||||||
| R1455R |
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody |
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|
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Donkey | PE | |||||
| OriGene Technologies GmbH | |||||||
| R1457C2 |
Mouse IgG (H+L chain), adsorbed antibody |
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|
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Goat | Cy2 | |||||
| OriGene Technologies GmbH | |||||||
| R1457C3 |
Mouse IgG (H+L chain), adsorbed antibody |
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|
|
Goat | Cy3 | |||||
| OriGene Technologies GmbH | |||||||
| R1457C5 |
Mouse IgG (H+L chain), adsorbed antibody |
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|
|
Goat | Cy5 | |||||
| OriGene Technologies GmbH | |||||||
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