WIF1 antibody

Principal name

WIF1 antibody

Alternative names for WIF1 antibody

WIF-1, UNQ191/PRO217, Wnt inhibitory factor 1

SwissProt ID

Q6IN38 (Rat), Q9W6F8 (Xenla), Q9W6F9 (Danre), Q9WUA1 (Mouse), Q9Y5W5 (Human)

Gene ID

11197 (WIF1), 24117 (Wif1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of WIF1 antibody

WIF-1 (Wnt Inhibitory Factor 1) is a secreted protein that binds to Wnt proteins and inhibits their activity. In situ hybridization analysis in Xenopus laevis and zebrafish indicate that the message is highly expressed in presomitic mesoderm, the notochord, anterior regions of the brain, branchial arches, nasal placodes, and otic vescicles. WIF-1 inhibits secondary axis induction by Wnts and promotes secondary axis induction by Chordin in Xenopus embryos. In vitro, WIF-1 binds to Drosophila Wingless and Xenopus Wnt8 proteins. WIF-1 is implicated as an early event tumor suppressor in cancers of the prostate, breast, lung, and bladder, while in other cancer types, such as colon adenocarcinoma, WIF-1 facilitates tumorigenesis. WIF-1 is also expressed in mammalian retina and may play a role in photoreceptor development. The protein is synthesized as a 379 amino acid (aa) molecule that contains a signal sequence, a 150 aa WIF domain, 5 EGF-like repeats, and a hydrophilic domain at the carboxy terminus.

General readings

Park JH., et al. (2014) Dev. Biol. 386(1):227-236.Stock M., et al. (2013) Arthritis Rheum. 65(9):2310-2322.

3 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

WIF1 (N-term) antibody

  Rabbit Polyclonal Antibody against WIF1 (N-term)  
Western blot analysis of WIF1 (arrow) using rabbit polyclonal WIF1 Antibody (N-term) (Cat.#TA302106). Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / $415.00
  OriGene Technologies, Inc.

WIF1 (C-term) antibody

  Rabbit Polyclonal Antibody against WIF1 (C-term)  
Western blot analysis of WIF1 (arrow) using rabbit polyclonal WIF1 (C-term) Antibody (Cat.#TA302107). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the WIF1 gene (Lane 2) (Origene Technologies). Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / $415.00
  OriGene Technologies, Inc.

WIF1 antibody

  Rabbit anti-WIF1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using WIF1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / $335.00
  OriGene Technologies, Inc.

3 Item(s)

per page
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