TMEM59 antibody
Principal name
TMEM59 antibody
Alternative names for TMEM59 antibody
C1orf8, HSPC001, Transmembrane protein 59, Liver membrane-bound protein
Ncbi ID
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)
Background of TMEM59 antibody
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
Sample (50 ug of whole cell lysate). A: mouse liver. 10% SDS PAGE. TA308979 diluted at 1:1000.
TMEM59 antibody detects TMEM59 protein by Western blot analysis. A. 50 ug rat kidney lysate/extract. 10 % SDS-PAGE. TMEM59 antibody (TA308979) dilution: 1:1000
Sample(30 ug of whole cell lysate). A:A431. 12% SDS PAGE. TA308979 diluted at 1:500
TMEM59 antibody detects TMEM59 protein at cytosol on human ovarian carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human ovarian carcinoma. TMEM59 antibody (TA308979) dilution: 1:500.
TMEM59 antibody detects TMEM59 protein at on mouse lung by immunohistochemical analysis. Sample: Paraffin-embedded mouse lung. TMEM59 antibody (TA308979) dilution: 1:500.
Western blot analysis of TMEM59 in human kidney tissue lysate with TMEM59 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of TMEM59 in human kidney tissue with TMEM59 antibody at 2.5 ug/mL.
Immunofluorescence of TMEM59 in human kidney tissue with TMEM59 antibody at 20 ug/mL.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA319781 | TMEM59 (N-term) antibody |
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| Rabbit Polyclonal TMEM59 Antibody | |||||||
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Rabbit | Aff - Purified | Hu | E, WB |
0.1 mg /
$415.00
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| OriGene Technologies, Inc. | |||||||
 +2 additional images |
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