POLR3G antibody
Principal name
POLR3G antibody
Alternative names for POLR3G antibody
RNA polymerase III subunit C7, RPC7, RPC32, DNA-directed RNA polymerase III subunit RPC7, DNA-directed RNA polymerase III subunit G, RNA polymerase III 32 kDa subunit
Gene ID
10622 (POLR3G)
Ncbi ID
Available reactivities
Available hosts
Available applications
ELISA (detection) (E(detection)), Western blot / Immunoblot (WB)
Background of POLR3G antibody
D-dependent R polymerase catalyzes the transcription of D into R using the four ribonucleoside triphosphates as substrates. POLR3G is a specific peripheric component of R polymerase III which synthesizes small Rs, such as 5S rR and tRs. It may direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex R Pol III binding to the TFIIIB-D complex via the interactions between TFIIIB and POLR3F. It may be involved either in the recruitment and stabilization of the subcomplex within R polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3G plays a key role in sensing and limiting infection by intracellular bacteria and D viruses. POLR3G acts as nuclear and cytosolic D sensor involved in inte immune response. POLR3G can sense non-self dsD that serves as template for transcription into dsR. The non-self R polymerase III transcripts, such as Epstein-Barr virus-encoded Rs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
