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NSUN2 antibody

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Principal name

NSUN2 antibody

Alternative names for NSUN2 antibody

SAKI, TRM4, tRNA (cytosine-5-)-methyltransferase NSUN2, NOL1/NOP2/Sun domain family member 2, tRNA (cytosine-5-)-methyltransferase, tRNA methyltransferase 4 homolog, Substrate of AIM1/Aurora kinase B

SwissProt ID

Q08J23 (Human), Q1HFZ0 (Mouse), Q9W4M9 (Drome)

Gene ID

54888 (NSUN2), 28114 (Nsun2)

Ncbi ID

NP_060225, NP_001180384, NP_663329.3, NM_017755, NP_001180384.1, NM_145354

Available reactivities

Bov (Bovine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of NSUN2 antibody

Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. NSUN2 is a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA).Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA) (Brzezicha et al., 2006 [PubMed 17071714]).[supplied by OMIM].

General readings

Huttenhofer,A., (2007) Mol. Biol. Cell 18 (3), 1107-1117

ARP48811_P050 - NSUN2
Human HeLa; WB Suggested Anti-NSUN2 Antibody Titration: 0.2-1 ug/ml. Positive Control: Hela cell lysate; NSUN2 antibody - C-terminal region (ARP48811_P050) in Human HeLa cells using Western Blot
AP52942PU-N - NSUN2
NSUN2 Antibody (Center) (Cat. #AP52942PU-N) western blot analysis in mouse spleen tissue lysates (35µg/lane).This demonstrates the NSUN2 antibody detected the NSUN2 protein (arrow).
TP314459 - NSUN2
TA346789 - NSUN2
WB Suggested Anti-NSUN2 Antibody Titration: 0.2-1 ug/ml; Positive Control: Hela cell lysate

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NSUN2 (Center) antibody
NSUN2 Antibody (Center) (Cat. #AP52942PU-N) western blot analysis in mouse spleen tissue lysates (35µg/lane).This demonstrates the NSUN2 antibody detected the NSUN2 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / $415.00
  OriGene Technologies GmbH

NSUN2 antibody
NSUN2 Rabbit Purified Ms C, E, WB
0.1 mg / $450.00
  OriGene Technologies GmbH

2 Item(s)

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Product Type
  1. Primary Antibody (2)
Clonality
  1. Polyclonal (2)
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  1. NSUN2 (2)
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  1. Center (1)
Reactivity
  1. Mouse (Ms) (2)
  2. Human (Hu) (1)
Applications
  1. Western blot / Immunoblot (WB) (2)
  2. Frozen sections (C) (1)
  3. Enzyme Immunoassay (E) (1)
Presentation
  1. Aff - Purified (1)
  2. Purified (1)
Images
  1. 1 image (1)
Images: Applications
  1. Western blot / Immunoblot (WB) (1)
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  1. OriGene Technologies (2)
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