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NOXA antibody

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Principal name

NOXA antibody

Alternative names for NOXA antibody

PMAIP1, Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1

SwissProt ID

Q13794 (Human), Q5U777 (Rat), Q9JM54 (Mouse)

Gene ID

5366 (PMAIP1), 58801 (Pmaip1), 492821

Ncbi ID

NP_066950.1, 10090, 9606, NP_067426.1, ADZ15689.1, AAH32663, NM_021127, NP_066950, NP_067426, NM_001008385

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Frozen Sections (C)

Background of NOXA antibody

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified , which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9 . Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53 (1-3). Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development (4).

General readings

Bai Y, Ahmad U, Wang Y, Li JH, Choy JC, Kim RW, Kirkiles-Smith N, Maher SE, Karras JG, Bennett CF, Bothwell AL, Pober JS, Tellides G.
Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation.
J Biol Chem. 2008 Mar 14;283(11):6832-42. Epub 2008 Jan 11.
PMID: 18192275

AP07195PU-N - NOXA
Immunohistochemistry staining of human brain / cortex (Formalin-fixed, Paraffin-embedded tissue after heat-induced antigen retrieval) using NOXA antibody Cat.-No. AP07195PU-N (concentration 10 ug/ml).
AP07195PU-N - NOXA
Western blot analysis of Noxa in A) human, B) mouse, and C) rat thymus tissue using NOXA antibody Cat.-No. AP07195PU-N at 2 ug/ml.
AP07509PU-N - NOXA
AP07509PU-N NOXA antibody staining of Formalin-Fixed Paraffin-Embedded Huuman Pancreas at 5 ug/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen.
AP05558PU-N - NOXA
Formalin fixed, paraffin embedded human stomach stained with Rabbit anti human NOXA (AP05558PU-N) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
AP05558PU-N - NOXA
Western blot analysis of whole cell lysate from HeLa cells probed with Rabbit anti Human NOD2 (AP05558PU-N) at 2(A) and 4(B) µg/ml
PAB0201 - NOXA
Western blot analysis of Pmaip1 in A ) human, B ) mouse, and C ) rat thymus tissue using Pmaip1 polyclonal antibody ( Cat # PAB0201 ) at 2 µg/ml.
MAB0093 - NOXA
Western blot detection of PMAIP1 in RL-7 cell ( a follicular lymphoma ) lysate. A protein of approximate molecular weight of 11 kDa is detected. Using PMAIP1 monoclonal antibody, clone 114C307.1 ( Cat # MAB0093 ) at 2 µg/ml.
PAB12863 - NOXA
Immunohistochemistry of Pmaip1 in human stomach tissue with Pmaip1 polyclonal antibody ( Cat # PAB12863 ) at 1 µg/ml.
PAB12863 - NOXA
Western blot analysis of Pmaip1 in human stomach tissue lysate with Pmaip1 polyclonal antibody ( Cat # PAB12863 ) at 0.5, 1 and 2 µg/ml.
PAB8873 - NOXA
Western blot analysis of PMAIP1 expression in Jurkat cell lysate.
TP302071 - NOXA
TA306071 - NOXA
Western blot analysis of Noxa in human stomach tissue lysate with Noxa antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
TA306071 - NOXA
Immunohistochemistry of Noxa in human stomach tissue with Noxa antibody at 1 ug/ml.
TA306071 - NOXA
Immunofluorescence of Noxa in Human Stomach cells with Noxa antibody at 10 ug/mL.
TA311499 - NOXA
(0.03ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
TA318945 - NOXA
Western blot analysis of Noxa expression in Jurkat cell lysate.
TA336343 - NOXA
Western Blot: Noxa Antibody [TA336343] - Noxa expression was stably reduced in HCT116 cells by shRNA. Image from verified customer review.
TA336343 - NOXA
Western Blot: Noxa Antibody [TA336343] - Western blot analysis of Noxa in A) human, B) mouse, and C) rat thymus tissue using TA336343 at 2 ug/ml.
TA336673 - NOXA
Western Blot: Noxa Antibody (114C307.1) [TA336673] - detection of Noxa antibody in A) 293 cells transfected with human Noxa, B) RL-7 cell (a follicular lymphoma) and C) T98G lysate using this antibody.
TA336673 - NOXA
Immunohistochemistry-Paraffin: Noxa Antibody (114C307.1) [TA336673] - Bouin-fixed, paraffin-embedded Chronic Lymphocytic Leukemia (CLL) xenograft stained with Noxa antibody (1:2000), peroxidase-conjugate and DAB chromogen. Staining for 2 hr at RT was used
TA336673 - NOXA
Immunocytochemistry/Immunofluorescence: Noxa Antibody (114C307.1) [TA336673] - Noxa antibody was tested in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). An antibody dilution of 1:

6 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NOXA antibody
  Rabbit Polyclonal Noxa Antibody  
Western blot analysis of Noxa in human stomach tissue lysate with Noxa antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / $415.00
  OriGene Technologies, Inc.
+2 additional images

NOXA antibody
  Rabbit polyclonal anti-Noxa antibody  
Western blot analysis of Noxa expression in Jurkat cell lysate. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / $355.00
  OriGene Technologies, Inc.

NOXA antibody
  Rabbit Polyclonal Noxa Antibody  
Western Blot: Noxa Antibody [TA336343] - Noxa expression was stably reduced in HCT116 cells by shRNA. Image from verified customer review. Rabbit Purified Hu, Ms, Rt P, WB
0.1 mg / $395.00
  OriGene Technologies, Inc.
+1 additional image

NOXA antibody
Formalin fixed, paraffin embedded human stomach stained with Rabbit anti human NOXA (AP05558PU-N) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0) Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / $410.00
  OriGene Technologies GmbH
+1 additional image

NOXA antibody
Immunohistochemistry staining of human brain / cortex (Formalin-fixed, Paraffin-embedded tissue after heat-induced antigen retrieval) using NOXA antibody Cat.-No. AP07195PU-N (concentration 10 ug/ml). Rabbit IgG Purified Hu, Ms, Rt P, WB
50 µg / $425.00
  OriGene Technologies GmbH
+1 additional image

NOXA antibody
AP07509PU-N NOXA antibody staining of Formalin-Fixed Paraffin-Embedded Huuman Pancreas at 5 ug/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / $425.00
  OriGene Technologies GmbH

6 Item(s)

per page

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  1. Primary Antibody (6)
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  3. Enzyme Immunoassay (E) (1)
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