HSPB2 antibody
Principal name
HSPB2 antibody
Alternative names for HSPB2 antibody
Heat shock protein beta-2, DMPK-binding protein, MKBP
Ncbi ID
9606, NP_001532, NP_001532.1, NP_001158180.1, NM_024441, NM_001164708, NM_130431, NM_001541
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)
Background of HSPB2 antibody
HSPB2, also known as MKBP is the most divergent member of the sHSP family with only 30% sequence identity to all other mammalian sHSPS . MKBP is known to associate specifically with myotonic dystrophy protein kise (DMPK) in skeletal muscle. MKBP enhances the kise activity of DMPK and protects it from heat-induced activation. MKBP also shows a unique ture compared to other sHSps, in that the expression of MKBP is not induced by heat shock . In unstressed skeletal muscle, MKBP forms large oligomeric complexes with HSPB3 in the cytosol which are localized on mitochondria and the neuromuscular junction . During stress, these complexes dissolve and MKBPs localization to mitochondria increases, leading to increased cell survival. Pinz et al. tried to find a distinct role for MKBP in terms of cardiac mechanics and finds that it is required for normal systolic performance and normal cardiac energetic . HSPB2 has also been found to be expressed in several cancer cell lines, including human breast cancer, suggesting that MKBP may be an important factor in tumor transformation and metastasis .
General readings
Suzuki A., et al. (1998) J. Cell Biol. 140:1113-1124Iwaki A., et al. (1997) Genomics. 45:386-394
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA313167 | HSPB2 antibody |
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| Rabbit polyclonal anti-HSPB2 antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | ICC/IF, WB |
0.1 ml /
$335.00
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| OriGene Technologies, Inc. | |||||||
 +1 additional image |
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