GPR109A antibody
Principal name
GPR109A antibody
Alternative names for GPR109A antibody
HM74A, NIACR1, Niacin receptor 1, Nicotinic acid receptor, PUMA-G, Pumag, G-protein coupled receptor 109A, G-protein coupled receptor HM74A
Ncbi ID
NP_808219, NM_177551, NP_808219.1, NP_109626.1, NM_030701, NM_181476
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)
Background of GPR109A antibody
NIACR1 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA351228 | GPR109A antibody |
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| Rabbit Polyclonal Anti-HCAR2 Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
$335.00
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| OriGene Technologies, Inc. | |||||||