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CXXC4 antibody

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Principal name

CXXC4 antibody

Alternative names for CXXC4 antibody

IDAX, CXXC-type zinc finger protein 4, Inhibition of the Dvl and axin complex protein

SwissProt ID

Q6NXI8 (Mouse), Q9EQC9 (Rat), Q9H2H0 (Human)

Gene ID

80319 (CXXC4), 319478 (Cxxc4), 83824

Ncbi ID

9606, NP_079488, NP_079488.1, NP_001004367.1, NM_001004367, BC067052, NM_053342, NM_025212

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E)

Background of CXXC4 antibody

CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.

General readings

Kojima, T., et al. Oncogene 28(2):297-305 (2009)
Hino, S., et al. Mol. Cell. Biol. 21(1):330-342 (2001)

AP26295CP-N - CXXC4
Western blot analysis of CXXC4 in human brain tissue lysate with CXXC4 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
AP51153PU-N - CXXC4
Formalin-fixed, paraffin-embedded human colon carcinoma reacted with CXXC4 antibody Cat.-No. AP51153PU-N (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
AP51153PU-N - CXXC4
Western blot analysis of CXXC4 antibody Cat.-No. AP51153PU-N in mouse testis tissue lysates (35ug/lane).
AP51153PU-N - CXXC4
Western blot analysis in K562 cell line lysates (35ug/lane) using CXXC4 antibody Cat.-No. AP51153PU-N. This demonstrates the CXXC4 antibody detected the CXXC4 protein (arrow).
AP51153PU-N - CXXC4
Flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram) using CXXC4 antibody Cat.-No. AP51153PU-N .FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
AP32075PU-N - CXXC4
AP32075PU-N CXXC4 Antibody staining of paraffin embedded Human Breast at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
TA320030 - CXXC4
Western blot analysis of CXXC4 in human brain tissue lysate with CXXC4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
TA320030 - CXXC4
Immunohistochemistry of CXXC4 in human brain tissue with CXXC4 antibody at 10 ug/mL.
TA320030 - CXXC4
Immunofluorescence of CXXC4 in human brain tissue with CXXC4 antibody at 20 ug/mL.
TA337976 - CXXC4
WB Suggested Anti-CXXC4 Antibody; Titration: 1.0 ug/ml; Positive Control: MCF7 Whole Cell
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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CXXC4 (C-term) antibody
Formalin-fixed, paraffin-embedded human colon carcinoma reacted with CXXC4 antibody Cat.-No. AP51153PU-N (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / $415.00
  OriGene Technologies GmbH
+3 additional images

Highly validated antibody!

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  1. Primary Antibody (1)
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  1. Human (Hu) (1)
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  1. Flow cytometry (F) (1)
  2. Paraffin Sections (P) (1)
  3. Western blot / Immunoblot (WB) (1)
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  1. Aff - Purified (1)
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  2. 3+ images (1)
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  1. Flow cytometry (F) (1)
  2. Paraffin Sections (P) (1)
  3. Western blot / Immunoblot (WB) (1)
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