Aromatase antibody
Principal name
Aromatase antibody
Alternative names for Aromatase antibody
Cytochrome P450 19A1, CYPXIX, Estrogen synthetase, P450AROM, CYP19A1, ARO1, CYAR, CYP19
SwissProt ID
O46512 (Horse), P11511 (Human), P19098 (Chick), P22443 (Rat), P28649 (Mouse), P46194 (Bovin)
Ncbi ID
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Frozen Sections (C), ELISA (detection) (E(detection))
Selected product citations ‐ of SM2222P
1. Colette S, Lousse JC, Defrère S, Curaba M, Heilier JF, Van Langendonckt A, et al. Absence of aromatase protein and mRNA expression in endometriosis. Hum Reprod. 2009 Sep;24(9):2133-41. doi: 10.1093/humrep/dep199. Epub 2009 Jun 2. PubMed PMID: 19493871.
2. Bender RA, Zhou L, Wilkars W, Fester L, Lanowski JS, Paysen D, et al. Roles of 17ß-estradiol involve regulation of reelin expression and synaptogenesis in the dentate gyrus. Cereb Cortex. 2010 Dec;20(12):2985-95. doi: 10.1093/cercor/bhq047. Epub 2010 Apr 26. PubMed PMID: 20421250.
3. Horling K, Santos AN, Fischer B. The AhR is constitutively activated and affects granulosa cell features in the human cell line KGN. Mol Hum Reprod. 2011 Feb;17(2):104-14. doi: 10.1093/molehr/gaq074. Epub 2010 Sep 7. PubMed PMID: 20823264.
4. Schicht M, Ernst J, Nielitz A, Fester L, Tsokos M, Guddat SS, et al. Articular cartilage chondrocytes express aromatase and use enzymes involved in estrogen metabolism. Arthritis Res Ther. 2014 Apr 11;16(2):R93. doi: 10.1186/ar4539. PubMed PMID: 24725461.
5. Zhao, Y;Yu, Y;Zhang, Y;He, L;Qiu, L;Zhao, J;Liu, M;Zhang, J. Letrozole regulates actin cytoskeleton polymerization dynamics in a SRC-1 dependent manner in the hippocampus of mice. J. Steroid Biochem. Mol. Biol. 2016. PubMed PMID: 27866972.
6. Fouquet, B;Santulli, P;Noel, JC;Misrahi, M. Ovarian-like differentiation in eutopic and ectopic endometrioses with aberrant FSH receptor, INSL3 and GATA4/6 expression. BBA Clin 2016, 143-152, 6. PubMed PMID: 27882303.
Background of Aromatase antibody
P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. P450 enzymes can be classified, based on their sequence similarities, into distinct subfamilies, which include CYP1A and CYP2A. Other P450 family members include CYP19, also designated aromatase (P450arom), which catalyzes the conversion of C19 steroids to estrogens in various tissues, including placent,a gonads, adipose tissue, skin and brain. CYP19 expression is controlled by hormonally regulated promoters in different tissues and increased aromatase activity is associated with familial gynecomastia. Also, a polymorphic allele of CYP19 (repeat (TTTA)12) is present in a majority of breast cancer patients. P450 cholesterol 7α-hydroxylase, CYP7A1, is the rate limiting enzyme of bile acid synthesis in the liver, and its expression is mediated by the bile acid receptor FXR. CYP27A1 catalyzes vitamin D 25-hydroxylation and is localized to the mitochondria in kidney and liver.
General readings
1. Van Poznak CH, Hayes DF. Aromatase inhibitors for the treatment of breast cancer: is tamoxifen of historical interest only?
J Natl Cancer Inst. 2006 Sep 20;98(18):1261-3. No abstract available.
PMID: 16985239
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Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AP00001PU-N | Aromatase antibody |
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Rabbit | Purified | Bov, Chk, Eq, Hu, Ms, Por, Rb, Rt, Sh | P, WB |
0.1 mg /
$440.00
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| OriGene Technologies GmbH | |||||||
 +2 additional images |
Top Selling product! Published recently! |
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