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PA055X FGF basic / FGF2 (154 amino acids)

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FGF basic / FGF2

PA055X

Product Description for FGF basic / FGF2

FGF basic / FGF2.
Presentation: Purified

Properties for FGF basic / FGF2

Product Category Proteins & Growth Factors
Target Category
Quantity 50 µg
Synonyms BFGF, FGFB, Fibroblast growth factor 2 (basic), HBGF-2, HBGF2, Heparin-binding growth factor 2
Presentation Purified
Molecular weight 17.2 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P09038
Purity > 95 % pure by SDS-PAGE and HPLC analyses
Add. information Centrifuge the vial prior to opening.
Background FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland liver, monocytes, epithelial cells and endothelial cells.
FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4.
Storage Prior to reconstitution store at 2-8°C for 6 months, at RT for one month 
or at -20°C to -80°C for longer.
Following reconstitution store undiluted at 2-8°C for one month
or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Recombinant human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues.
AA Sequence:
AAGSITTLPA LPEDGGSGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHIK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTDEC FFFERLESNN YNTYRSRKYT SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS
Biological activity:

Assay 1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
Assay 2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
Molecular weight:
(154 aminon acids)
Format
Buffer System:
5 mM Tris, pH 7.6, containing 150 mM NaCl
Endotoxin level:
< 0.1 ng per µg (1EU/µg)
Purity:
>95% pure by SDS-PAGE and HPLC analyses
State:
Lyophilized (0.2µ Sterile filtered) purified protein
Purified
Reconstitution:
Restore in 5 mM Tris, pH 7.6, to a concentration of 0.1-1.0 mg/ml.
This solution can then be diluted into other aqueous buffers and stored at 4°C for one week or at -20°C for future use.
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