Product Description for Uroplakin-3a (UPK3A)
Uroplakin-3a (UPK3A).
Presentation: Purified
Presentation: Purified
Properties for Uroplakin-3a (UPK3A)
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.25 mg |
| Synonyms | UP3a, UPIII, UPK3, Uroplakin III |
| Presentation | Purified |
| Molecular weight | 23.1 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
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| Purity | > 90 % by SDS - PAGE |
| Background | UPK3A belongs to the uroplakin-3 family. Uroplakins (UP) are key components of the urothelium. They are transmembrane proteins that pass the lipid bilayer once (UPII, UPIIIa, and UPIIIb) or four times (UPIa and UPIb; both belonging to the 'tetraspanin' family). All have large luminal/extracellular domains, but only UPIIIa and UPIIIb have significant cytoplasmic portions in their C-termini. UPK3A is a highly specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Mutations in this gene may be associated with renal adysplasia |
| Concentration | 0.25mg/ml (determined by Bradford assay) |
| General Readings | Shapiro, E., et al. (2000) J. Urol. 164: 1048-1051.Wu, X.R., et al. (1994) J. Biol. Chem. 269:13716-13724. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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