Product Description for DR1 / NC2-beta
DR1 / NC2-beta.
Presentation: Purified
Presentation: Purified
Properties for DR1 / NC2-beta
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.5 mg |
| Synonyms | Down-regulator of transcription 1, Negative cofactor 2-beta, TATA-binding protein-associated phosphoprotein |
| Presentation | Purified |
| Molecular weight | 21.6 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Purity | > 85 % by SDS-PAGE |
| Background | DR1, also known as NC2-beta, is a TBP (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. By selectively repressing polymerases II and III, DR1 may shift the physiological balance of transcriptional output in favor of polymerase I. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | White RJ., et al. (2010) Nucleic Acids Res. 38(4):1228-39. Collart MA., et al. (2008) Nucleic Acids Res. 36(2):539-49. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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