Product Description for HEXIM1
HEXIM1.
Presentation: Purified
Presentation: Purified
Properties for HEXIM1
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | CLP1, Cardiac lineage protein 1, EDG1, Estrogen down-regulated gene 1 protein, HIS1, Hexamethylene bis-acetamide-inducible protein 1, MAQ1, Menage a quatre protein 1 |
| Presentation | Purified |
| Molecular weight | 44.8 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 90 % by SDS - PAGE |
| Background | HEXIM1 is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This protein has been shown to form a protein-RNA complex composed of 7SK small nuclear RNA and positive transcription elongation factor b (P-TEFb), which is composed of cyclin-dependent kinase 9 (CDK9) and cyclin T1, and to inhibit the kinase activity of CDK9, thereby suppressing RNA polymerase II-dependent transcriptional elongation. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Shimizu N., et al. (2005) Proc. Natl. Acad. Sci. U.S.A. 102(24):8555-60 |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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