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AP05244PU-N TLR11 antibody

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0.1 mg / $480.00
Delivery Time: 3-5 working days*
(*) valid for US customers only

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Quick Overview

Rabbit anti Mouse TLR11

AP05244PU-N

Product Description for TLR11

Rabbit anti Mouse TLR11.
Presentation: Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for TLR11

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Gm287, Toll-like receptor 11
Presentation Purified
Reactivity Ms
Applications C, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Molecular weight 106 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q6R5P0
Immunogen:
Peptide corresponding to 16 amino acids near the middle of mouse TLR11
GeneID:
239081
Application Western Blot: 0.5-2 µg/ml.
Positive Control RAW26.7 Cell Lysate.
Immunohistochemistry.
Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5). TLR11 is one of three mouse TLRs that lack a human ortholog (6). It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system (7).
Concentration Lot specific
General Readings
  1. Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like 1. Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.
  2. Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335–76.
  3. Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
  4. O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.
  5. McGettrick AF and O'Neill LAJ. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Imm. 2004; 41:577-82.
  6. Tabeta K, Georgel P, Janseen E, et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Nat'l. Acad. Sci. USA 2004; 101:3516-3521.
  7. Zhang D, Zhang G, Hayden MS, et al. A Toll-like receptor that prevents infection by uropathogenic bacteria. Science 2004; 303:1522-6. (RD1005)
  8. UniProtKB/Swiss-Prot entry Q6R5P0, http://www.expasy.org/uniprot/Q6R5P0, Accessed February 16, 2007.
Storage Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Format
Buffer System:
Phosphate buffered saline with 0.02% sodium azide
Purity:
Purified
State:
Liquid purified Ig fraction
Purified
Specificity
Specificity:
This antibody detects TLR11. Located in the membrane.
Species:
Mouse.
Gene ID 239081

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Click here to see all secondary antibodies for TLR11
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