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TA306374 FAF1 (C-term) antibody

Rabbit Polyclonal FAF1 Antibody

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Search for all "FAF1"

0.1 mg / $415.00
Delivery Time: 5-7 working days*
(*) valid for US customers only

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Rabbit anti Human, Mouse, Rat FAF1

TA306374

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  • TA306374
  • TA306374

Product Description for FAF1

Rabbit anti Human, Mouse, Rat FAF1.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for FAF1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms CGI-03, FAS-associated factor 1, UBX domain-containing protein 12, UBX domain-containing protein 3A, UBXD12, UBXN3A
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9UNN5
Immunogen:
FAF1 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human FAF1. (AP30327CP-N)
GeneID:
11124
Property C-term
Add. information Blocking peptide available: blocking peptide (AP30327CP-N)
Application ELISA.
Western Blot: 1 – 2 μg/ml.
Immunohistochemistry.
Background Fas-associated protein 1 (FAF1) was initially identified as a Fas-binding pro-apoptotic protein that is component of the death-inducing signaling complex in Fas-mediated apoptosis (1). FAF1 can also induce apoptosis in the absence of extrinsic death signals when overexpressed although it does not contain typical death motifs such as the death domain, death effector domain, and caspase recruitment domain (1,2). Overexpression of FAF1 also decreases the basal level of NF-kappaB activity in transfected 293 cells, inhibits NF-kappaB activity induced by TNF-alpha, IL-1beta and lipopolysaccharide, and prevents NF-kappaB translocation to the nucleus (3), suggesting that another role of FAF1 is to negatively regulate the activity of NF-kappaB. FAF1 can also interact with the inflammatory signaling PYRIN-containing Apaf-1-like proteins (PYPAFs, also called NALPs) such as PYPAF1, PYPAF2 (NALP2), and PYPAF7, suggesting FAF1 may also be involved in the inflammation pathway (4). Multiple differentially spliced isoforms of FAF1 are known to exist.
General Readings
  1. Chu K, Niu X, Williams LT. A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11894-8. PubMed PMID: 8524870. (Free PMC Article available)
  2. Ryu SW, Kim E. Apoptosis induced by human Fas-associated factor 1, hFAF1, requires its ubiquitin homologous domain, but not the Fas-binding domain. Biochem Biophys Res Commun. 2001 Sep 7;286(5):1027-32. PubMed PMID: 11527403.
  3. Park MY, Jang HD, Lee SY, Lee KJ, Kim E. Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB. J Biol Chem. 2004 Jan 23;279(4):2544-9. Epub 2003 Nov 4. PubMed PMID: 14600157.
  4. Kinoshita T, Kondoh C, Hasegawa M, et al. Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1. Int. Immunol. 2006;18:1701-6.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide.
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
This antibody reacts to FAF1.
Species:
Human, Mouse, Rat.

Accessory Products

Proteins and/or Positive Controls

Proteins for FAF1 (1 products)

Catalog No. Species Pres. Purity   Source  

FAF1
FAF1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. 		HEK293 cells
20 µg / $748.00
  OriGene Technologies, Inc.

Positive controls for FAF1 (1 products)

Catalog No. Species Pres. Purity   Source  

FAF1 overexpression lysate
FAF1 overexpression lysate
0.1 mg / $295.00
  OriGene Technologies, Inc.

Recommended Secondary Antibodies for FAF1 (9 products)

Catalog No. Host Clone/Iso. Pres.   React. Applications  

Rabbit IgG (H+L chain) antibody
Rabbit IgG (H+L chain) antibody Goat AP Rb E, WB
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Rabbit IgG (H+L chain) antibody
Rabbit IgG (H+L chain) antibody Goat Biotin Rb E, WB
    OriGene Technologies GmbH

Rabbit IgG (H+L chain) antibody
Rabbit IgG (H+L chain) antibody Goat FITC Rb E, ICC/IF, WB
    OriGene Technologies GmbH

Rabbit IgG (H+L chain) antibody
Rabbit IgG (H+L chain) antibody Goat HRP Rb E, P, WB
    OriGene Technologies GmbH

Rabbit IgG (H+L chain) antibody
Rabbit IgG (H+L chain) antibody Goat TRITC Rb E, F, ICC/IF
    OriGene Technologies GmbH

Rabbit IgG F(ab)2 Fragment (H+L chain) antibody
Rabbit IgG F(ab)2 Fragment (H+L chain) antibody Donkey PE Rb F
    OriGene Technologies GmbH

Rabbit IgG (H+L chain, adsorbed) antibody
Rabbit IgG (H+L chain, adsorbed) antibody Goat Cy2
    OriGene Technologies GmbH

Rabbit IgG (H+L chain, adsorbed) antibody
Rabbit IgG (H+L chain, adsorbed) antibody Goat Cy3
    OriGene Technologies GmbH

Rabbit IgG (H+L chain, adsorbed) antibody
Rabbit IgG (H+L chain, adsorbed) antibody Goat Cy5
    OriGene Technologies GmbH
Click here to see all secondary antibodies for FAF1
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