Product Description for EBI3 / IL27B
Rat anti Mouse EBI3 / IL27B 5P6G8.
Presentation: Purified
Product is tested for Flow Cytometry, Western blot / Immunoblot.
Presentation: Purified
Product is tested for Flow Cytometry, Western blot / Immunoblot.
Properties for EBI3 / IL27B
| Product Category | Primary Antibodies |
|---|---|
| Target Category | |
| Quantity | 0.1 mg |
| Synonyms | EBV-induced gene 3 protein, Epstein-Barr virus-induced gene 3 protein, IL-27 subunit beta, IL-27B, Interleukin-27 subunit beta |
| Presentation | Purified |
| Reactivity | Ms |
| Applications | F, WB |
| Clonality | Monoclonal |
| Clone | 5P6G8 |
| Host | Rat |
| Isotype | IgG2b |
| Shipping to | Europe, USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies, Inc. |
Datasheet Extract
| Immunogen |
|
|---|---|
| Application | WB: 0.5-5 ug/ml FC: 1-3ug/10^6cells |
| Background | EBI3 (Epstein-Barr virus Induced-3) is a secreted glycoprotein of the hematopoietin receptor family. It plays a critical regulatory role in the induction of Th2-type immune responses and the development of Th2-mediated tissue inflammation in vivo, which may be mediated through the control of iNKT cell function. EBI3 dimerizes with p28 and p35 subunits of IL-12 to form new proteins IL-27 and IL-35, respectively (Honglian Tong et al, 2010). IL-27 is an early product of activated antigen presenting cell that is produced upon TLR ligation. It negatively regulates Th17 cell differentiation. EBI3 is widely expressed and its expression in dendritic cell is transcriptiolly regulated by TLR sigling via MyD88 and NF-kappaB during inte immune responses preceding cytokine driven Th cell development. EBI3 sigl inhibits delayed-type hypersensitivity responses by suppressing IL-17 production and inducing IL-10 hyperproduction. EBI3 may play a novel role in controlling tumor metastasis via lung CD8+ T cells, and its deficiency is associated with a diminished production of Th2 cytokines which are known to regulate allergic airway inflammation in asthma. Targeted deletion of EBI3 protects mice from lung metastasis (Kerstin A et al, 2008). |
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Accessory Products
Proteins and/or Positive Controls
Proteins for EBI3 / IL27B (1 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| TP723851 |
EBI3 / IL27B |
||||||
|
Human |
> 95 % Preparation: . Purity Detail: >95%, as determined by Coomassie stained SDS-PAGE. |
CHO cells |
10 µg /
$355.00
|
|||
| OriGene Technologies, Inc. | |||||||
Positive controls for EBI3 / IL27B (1 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| LY417095 |
EBI3 overexpression lysate |
||||||
|
0.1 mg /
$295.00
|
||||||
| OriGene Technologies, Inc. | |||||||
Recommended Secondary Antibodies for EBI3 / IL27B (11 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1371AP |
Rat IgG (H+L chain) antibody |
||||||
|
|
Rabbit | AP | |||||
| OriGene Technologies GmbH | |||||||
| R1371B |
Rat IgG (H+L chain) antibody |
||||||
|
|
Rabbit | Biotin | |||||
| OriGene Technologies GmbH | |||||||
| R1371F |
Rat IgG (H+L chain) antibody |
||||||
|
|
Rabbit | FITC | |||||
| OriGene Technologies GmbH | |||||||
| R1371HRP |
Rat IgG (H+L chain) antibody |
||||||
|
|
Rabbit | HRP | C, E, WB | ||||
| OriGene Technologies GmbH | |||||||
| R1371T |
Rat IgG (H+L chain) antibody |
||||||
|
|
Rabbit | TRITC | |||||
| OriGene Technologies GmbH | |||||||
| R1413R |
Rat IgG (H+L chain), F(ab)2 Fragment antibody |
||||||
|
|
Goat | PE | |||||
| OriGene Technologies GmbH | |||||||
| R1415R |
Rat IgG F(ab)2 specific (adsorbed F(ab)2 Fragment) antibody |
||||||
|
|
Goat | PE | |||||
| OriGene Technologies GmbH | |||||||
| R1428R |
Rat IgG (H+L chain) F(ab')2 Fragment antibody |
||||||
|
|
Donkey | PE | |||||
| OriGene Technologies GmbH | |||||||
| R1439C2 |
Rat IgG (H+L chain, adsorbed) antibody |
||||||
|
|
Goat | Cy2 | |||||
| OriGene Technologies GmbH | |||||||
| R1439C3 |
Rat IgG (H+L chain, adsorbed) antibody |
||||||
|
|
Goat | Cy3 | |||||
| OriGene Technologies GmbH | |||||||
| R1439C5 |
Rat IgG (H+L chain, adsorbed) antibody |
||||||
|
|
Goat | Cy5 | |||||
| OriGene Technologies GmbH | |||||||
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