Product Description for CACNA1E
Rabbit anti Human, Mouse, Rat CACNA1E.
Presentation: Purified
Product is tested for Western blot / Immunoblot.
Presentation: Purified
Product is tested for Western blot / Immunoblot.
Properties for CACNA1E
| Product Category | Primary Antibodies |
|---|---|
| Target Category | |
| Quantity | 0.2 ml |
| Synonyms | Brain calcium channel II, CACH6, CACNL1A6, Cav2.3, Voltage-dependent R-type calcium channel subunit alpha-1E, Voltage-gated calcium channel subunit alpha |
| Presentation | Purified |
| Reactivity | Hu, Ms, Rt |
| Applications | WB |
| Clonality | Polyclonal |
| Host | Rabbit |
| Shipping to | Europe, USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies, Inc. |
Datasheet Extract
| Immunogen |
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|---|---|
| Application | WB: 1:200-1:2000; IHC: 1:100-1:3000 |
| Background | Voltage-dependent Ca2+ channels (Cav channels) are pivotal players in many physiological roles such as secretion, contraction, migration and excitation.The voltage dependent Ca2+ channels are composed of several subunits; a1, Ã?, a2d and ?. Cav channels were origilly divided into six physiological types: L, N , P, Q, R, and T type.The Cav2.3 (formerly med a1E) protein, forms the R type channels. R-type channels are highly sensitive to both SNX-482 (#RTS-500) and NiCl2. Cav2.3 channels were shown to mediate fast excitatory transmission in several sypses including the hippocampus.Cav2.3 channels can be modulated by the muscarinic G-protein coupled receptors. In HEK-293 cells, expressing Cav2.3 channels, the R-type channel was shown to be both facilitated and inhibited by m1 and m2 muscarinic receptors. However, inhibition was much weaker than facilitation for the m1 receptor, while for m2 receptors, inhibition was much more pronounced than activation.Facilitation and inhibition by the same receptors was probably exerted via different pathways as was indicated by their response to various inhibitors. |
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Accessory Products
Recommended Secondary Antibodies for CACNA1E (9 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1364AP |
Rabbit IgG (H+L chain) antibody |
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|
Goat | AP | Rb | E, WB | |||
| OriGene Technologies GmbH | |||||||
| R1364B |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | Biotin | Rb | E, WB | |||
| OriGene Technologies GmbH | |||||||
| R1364F |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | FITC | Rb | E, ICC/IF, WB | |||
| OriGene Technologies GmbH | |||||||
| R1364HRP |
Rabbit IgG (H+L chain) antibody |
||||||
|
Goat | HRP | Rb | E, P, WB | |||
| OriGene Technologies GmbH | |||||||
| R1364T |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | TRITC | Rb | E, F, ICC/IF | |||
| OriGene Technologies GmbH | |||||||
| R1427R |
Rabbit IgG F(ab)2 Fragment (H+L chain) antibody |
||||||
|
|
Donkey | PE | Rb | F | |||
| OriGene Technologies GmbH | |||||||
| R1458C2 |
Rabbit IgG (H+L chain, adsorbed) antibody |
||||||
|
|
Goat | Cy2 | |||||
| OriGene Technologies GmbH | |||||||
| R1458C3 |
Rabbit IgG (H+L chain, adsorbed) antibody |
||||||
|
|
Goat | Cy3 | |||||
| OriGene Technologies GmbH | |||||||
| R1458C5 |
Rabbit IgG (H+L chain, adsorbed) antibody |
||||||
|
Goat | Cy5 | |||||
| OriGene Technologies GmbH | |||||||
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