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TERF1 antibody

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Principal name

TERF1 antibody

Alternative names for TERF1 antibody

PIN2, TRBF1, TRF, TRF1, Telomeric repeat-binding factor 1, TTAGGG repeat-binding factor 1, NIMA-interacting protein 2, Telomeric protein Pin2/TRF1

SwissProt ID

P54274 (Human), P70371 (Mouse)

Gene ID

7013 (TERF1), 21749 (Terf1)

Ncbi ID

NP_003209.2, 9606, NP_003209, NP_059523.1, NP_033378.1, NM_009352, NM_003218, NM_017489

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Prim (Primate)

Available hosts

Mouse, Rabbit, Goat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TERF1 antibody

Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage.
TRF1 is thought to play a role in leukaemia being expressed at significantly higher levels in patients with acute lymphoblastic leukaemia than those with myeloid leukaemia.

General readings

Chong L, van Steensel B, Broccoli D, Erdjument-Bromage H, Hanish J, Tempst P, de Lange T.
A human telomeric protein.
Science. 1995 Dec 8;270(5242):1663-7.
PMID: 7502076

PAB0162 - TERF1
Western blot analysis of TERF1 in 20 µgs of ( A ) Jurkat and ( B ) 293 cell lysate. Using TERF1 polyclonal antibody ( Cat # PAB012 ) at 7 µg/ml.
PAB2607 - TERF1
Western blot analysis of TERF1 polyclonal antibody ( Cat # PAB2607 ) in Jurkat cell line lysates ( 35 µg/lane ) . TERF1 ( C-term ) ( arrow ) was detected using the purified polyclonal antibody ( 1 : 60 dilution ) .
PAB6118 - TERF1
TERF1 polyclonal antibody ( Cat # PAB6118 ) staining ( 2 µg/ml ) of HeLa lysate ( RIPA buffer, 30 µg total protein per lane ) . Primary incubated for 12 hour. Detected by western blot using chemiluminescence.
AP12398PU-N - TERF1
Western blot analysis of anti-TERF1(C-term) Pab (Cat.#AP12398PU-N) in Jurkat cell line lysates (35ug/lane). TERF1 (C-term)(arrow) was detected using the purified Pab (1:60 dilution).
MAB2400 - TERF1
Western blot analysis of TRF1 using TERF1 monoclonal antibody, clone 57-6 ( Cat # MAB2400 ). 50 µg of total lysate were used each lane.
MAB2400 - TERF1
Western blot analysis of TERF1 in HeLa whole cell extracts using TERF1 monoclonal antibody, clone 57-6 ( Cat # MAB2400 ).
AP20371PU-N - TERF1
Immunohistochemistry analyzes of TRF1 antibody (AP20371PU-N) in paraffin-embedded human brain tissue.
AP20371PU-N - TERF1
Western blot analysis of TRF1 antibody (AP20371PU-N) in extracts from 293 cells.
A1239-1 - TERF1
Western blot analysis of extracts from 293 cells treated with paclitaxel 1uM 24h, using Telomeric Repeat Binding Factor 1 (Phospho-Ser219) Antibody. The lane on the right is treated with the synthesized peptide.
B1239-1 - TERF1
Western blot analysis of extracts from 293 cells, treated with Paclitaxel 1uM 24h, using Telomeric Repeat Binding Factor 1 (Ab-219) Antibody. The lane on the right is treated with the synthesized peptide.
PRO-50044-0050 - TERF1
Human TERF1 (Telomeric repeat-binding factor 1) recombinant protein 6xHis tagged
PRO-50044-0025 - TERF1
Human TERF1 (Telomeric repeat-binding factor 1) recombinant protein 6xHis tagged
PRO-50044-0010 - TERF1
Human TERF1 (Telomeric repeat-binding factor 1) recombinant protein 6xHis tagged
PRO-50045-0050 - TERF1
Human TERF1 (Telomeric repeat-binding factor 1) recombinant protein 6xHis-GST tagged
PRO-50045-0025 - TERF1
Human TERF1 (Telomeric repeat-binding factor 1) recombinant protein 6xHis-GST tagged
PRO-50045-0010 - TERF1
Human TERF1 (Telomeric repeat-binding factor 1) recombinant protein 6xHis-GST tagged
CPA2144-100ul - TERF1
Western blot analysis of TERF1 (pS219) expression in DLD UV-treated (A); Raw264.7 UV-treated (B); PC12 UV-treated (C) whole cell lysates.
TP305904 - TERF1
TA302766 - TERF1
TA302766 staining (2µg/ml) of HeLa lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.
TA309899 - TERF1
Western Blot: TRF1 Antibody (57-6) - Western blot detection of TRF1. 50 ugs of total lysate each lane.
TA309899 - TERF1
Western Blot: TRF1 Antibody (57-6) - Detection of TRF1 in HeLa whole cell extracts
TA322886 - TERF1
Predicted band size: 50kDa. Positive control: Human fetal kidney tissue lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 50 ug Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 5 minutes)
TA322886 - TERF1
Predicted cell location: Cytoplasm . Positive control: Human colon cancer tissue . Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using TERF1 antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x200)
TA322887 - TERF1
Predicted band size: 50kDa. Positive control: 293T and Hela cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lane1:293T cell lysate Lane2: Hela cell lysate Lysates: 50 ug per lane Primary antibody: 1/200 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 5 minutes)
TA322887 - TERF1
Predicted cell location: Cytoplasm . Positive control: Human gastric cancer tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded human gastric cancer tissue using TERF1 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification:x200)
TA329083 - TERF1
TA329083 (0.3µg/ml) staining of Human Testis lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TERF1 antibody
  Mouse Monoclonal TRF1 Antibody (57-6)  
Western Blot: TRF1 Antibody (57-6) - Western blot detection of TRF1. 50 ugs of total lysate each lane. Mouse IgG1 57-6 Purified Hu, Ms, Prim, Rt E, ICC/IF, WB
0.1 ml / $415.00
  OriGene Technologies, Inc.
+1 additional image

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  2. Immunocytochemistry/​Immunofluorescence (ICC/IF) (1)
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