SENP2 antibody

Principal name

SENP2 antibody

Alternative names for SENP2 antibody

Sentrin-specific protease 2, Smt3ip2, Axam2, KIAA1331, Sentrin/SUMO-specific protease SENP2, SMT3-specific isopeptidase 2

SwissProt ID

Q91ZX6 (Mouse), Q9EQE1 (Rat), Q9HC62 (Human)

Gene ID

59343 (SENP2), 75826 (Senp2), 78973

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of SENP2 antibody

SUMO (small ubiquitin-related modifier), a member of the ubiquitin-like protein family, regulates diverse cellular functions of a variety of target proteins including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the “GG” region by SUMO-specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin-specific (or SUMO-specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1-3 and SENP5-8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates. HIPK2 is a desumoylation target for SENP1 which shuttles between the cytoplasm and the nucleus. Mutation analyses reveal that SENP1 contains the nuclear export sequence (NES) within the extreme carboxyl-terminal region, and SENP1 is exported to the cytoplasm in a NES-dependent manner. SENP2 has been implicated as a downregulator of CTNNB1 levels and may therefore be a modulator of the Wnt pathway. SUMO protease SENP3 reverses the sumoylation of MEF-2 to augment its transcriptional and myogenic activities. SENP5 localizes to the nucleolus and preferentially processes SUMO-3. It is thought to play a role in mitosis and/or cytokinesis.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SENP2 antibody

  Rabbit Polyclonal SENP2 Antibody  
Western Blot: SENP2 Antibody [TA336351] - analysis of SENP2 in human Jurkat (A) and mouse NIH 3T3 (B) cell lysate using SENP3 antibody at 3 ug/ml. Rabbit Purified Hu, Ms P, WB
0.1 mg / $335.00
  OriGene Technologies, Inc.

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