CDC7 antibody
Principal name
CDC7 antibody
Alternative names for CDC7 antibody
CDC7L1, CDC7-related kinase, HsCdc7, huCdc7, Cell division cycle 7-related protein kinase
Gene ID
8317 (CDC7)
Ncbi ID
9606, NP_001127891, NP_001127891.1, NP_003494.1 (Gene ID : 8317), NM_003503, NM_001134419, NM_001134420
Available reactivities
Available hosts
Available applications
Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C)
Background of CDC7 antibody
Cell division cycle-7 (CDC7) was initially discovered as a temperature sensitive cell cycle mutant in Saccharomyces cerevisiae. CDC7 is required in the mitotic cell cycle for the initiation of DNA synthesis. CDC7 forms a complex with a Dbf4-related regulatory subunit to generate an active Ser/Thr kinase that functions in DNA replication, repair, and mitotic recombination. CDC7-Dbf4 efficiently phosphorylates several proteins that are required for the initiation of DNA replication, including five of the six minichromosome maintenance (MCM) proteins and the p180 subunit of DNA polymerase alpha-primase. CDC7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. A human homolog of the yeast CDC7 is over-expressed in some tumors and transformed cell lines.
General readings
This antibody is used in these references:
1. Kim. B. J., et al., J. Biol. Chem 281, 12041-12049 (2006)
2. Liu. P., et al., J. Biol. Chem. 281, 30631-30644 (2006)
3. Yoshizawa-Sugata, N., et al., J. Biol. Chem. 280, 13062-13070 (2005).
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AP54835PU-N | CDC7 antibody |
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Rabbit | Purified | Hu, Ms | C, E, WB |
0.1 mg /
$450.00
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| OriGene Technologies GmbH | |||||||