Vasopressin V2 receptor (AVPR2) antibody

Principal name

Vasopressin V2 receptor (AVPR2) antibody

Alternative names for Vasopressin V2 receptor (AVPR2) antibody

AVPR V2, ADHR, DIR, DIR3, V2R, Renal-type arginine vasopressin receptor, Antidiuretic hormone receptor

SwissProt ID

O77808 (Canfa), O88721 (Mouse), P30518 (Human), P32307 (Pig), P48044 (Bovin), Q00788 (Rat)

Gene ID

554 (AVPR2), 12000 (Avpr2), 25108

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Mky (Monkey), Bt (Bat), Can (Canine), Chimp (Chimpanzee), Eq (Equine), Hst (Hamster), Rb (Rabbit), Gorilla, Prim (Primate), Bear, GP (Guinea Pig), Sh (Sheep)

Available hosts

Rabbit, Goat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of Vasopressin V2 receptor (AVPR2) antibody

This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members sigl via other G proteins. All bind similar cyclic nopeptide hormones. The V2 receptor is expressed in the kidney tubule, predomintly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarel receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with altertive splicing.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Vasopressin V2 receptor (AVPR2) antibody

Vasopressin V2 receptor (AVPR2) Rabbit Ig Fraction Bov, Hu, Ms, Por, Rt C, E, WB
50 µg / $1,300.00
  OriGene Technologies GmbH

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