PTPN21 / PTPD1 antibody

Principal name

PTPN21 / PTPD1 antibody

Alternative names for PTPN21 / PTPD1 antibody

Tyrosine-protein phosphatase non-receptor type 21, Protein-tyrosine phosphatase D1

SwissProt ID

Q16825 (Human), Q62136 (Mouse), Q62728 (Rat)

Gene ID

11099 (PTPN21)

Available reactivities

Hu (Human), Chk (Chicken), Mky (Monkey), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of PTPN21 / PTPD1 antibody

A Src-associated protein tyrosine phosphatase (PtpnD1/Ptpn21) is associated with AKAP121 and its splice variant AKAP88 complex in the mitochondrial or cell membrane that helps in focusing and enhancing the cAMP-signaling in the organelle. This signaling complex containing AKAP121, PKA, PTPD1, and src is assembled in vivo. PTPD1 activates src tyrosine kinase and increases the magnitude and duration of epidermal growth factor (EGF) signaling and cause an EGF receptor phosphorylation and downstream activation of ERK 1/2 and Elk1-dependent gene transcription are enhanced by PTPD1. The protein encoded by the ptpn gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1,ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis (1).
The Ptpn21 is a 135 kDa protein (1117 aa) soluble protein with multiple functional domains with N-terminal sequence homology to the ezrin-band 4.1-merlin-radixin protein family members. The expression of Ptpn was noted in a variety of tissues; the Ptpn is efficiently phosphorylated by and associated with the src kinase pp60src (2). Recent data indicate that PTPD1 and PTPD2 are expressed in a variety of tissues. In transient coexpression experiments PTPD1 was found to be efficiently phosphorylated by and associated with the src kinase pp60src. PTPD1 is a positive regulator of src signaling and a key component of the EGF transduction pathway. Upon binding of PtpnD1 and or targeting the phosphatase on mitochondria, AKAP121 modulates the amplitude and persistence of src-dependent EGF transduction pathway and established a functional interaction between AKAP and protein tyrosine phosphatase.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTPN21 / PTPD1 antibody

  Rabbit Polyclonal Anti-PTPN21 Antibody  
WB Suggested Anti-PTPN21 Antibody; Titration: 1.0 ug/ml; Positive Control: ACHN Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / $360.00
  OriGene Technologies, Inc.

PTPN21 / PTPD1 (Center) antibody

Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with PTPD1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu WB
0.4 ml / $415.00
  OriGene Technologies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  


  Recombinant protein of human protein tyrosine phosphatase, non-receptor type 21 (PTPN21)  
PTPN21 / PTPD1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / $788.00
  OriGene Technologies, Inc.


Catalog No.    

PTPN21 overexpression lysate

PTPN21 overexpression lysate  
0.1 mg / $495.00
  OriGene Technologies, Inc.

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