PAK4 antibody

Principal name

PAK4 antibody

Alternative names for PAK4 antibody

PAK 4, PAK-4, p21-activated kinase 4, KIAA1142, Serine/threonine-protein kinase PAK 4

SwissProt ID

O96013 (Human), Q8BTW9 (Mouse)

Gene ID

10298 (PAK4), 70584 (Pak4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Can (Canine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PAK4 antibody

The p21-activated kises (PAKs) are serine-threonine kises that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neurol development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.

General readings

Liu Y., et al. (2008). Mol Cancer Res. 6(7):1215-24.
Li X., et al. (2005). J Biol Chem. 280(50):41192-200.

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Catalog No. Species Donor Vector  

PAK4 - human gene knockout kit via CRISPR

PAK4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / $1,290.00
  OriGene Technologies, Inc.

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