PAK4 antibody

Principal name

PAK4 antibody

Alternative names for PAK4 antibody

PAK 4, PAK-4, p21-activated kinase 4, KIAA1142, Serine/threonine-protein kinase PAK 4

SwissProt ID

O96013 (Human), Q8BTW9 (Mouse)

Gene ID

10298 (PAK4), 70584 (Pak4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Can (Canine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PAK4 antibody

The p21-activated kises (PAKs) are serine-threonine kises that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neurol development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.

General readings

Liu Y., et al. (2008). Mol Cancer Res. 6(7):1215-24.
Li X., et al. (2005). J Biol Chem. 280(50):41192-200.

2 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PAK4 antibody

  Rabbit Polyclonal Anti-PAK4 Antibody  
Host: Rabbit; Target Name: PAK4; Sample Tissue: ACHN Whole cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Rb, Rt WB
50 µg / $360.00
  OriGene Technologies, Inc.

PAK4 (incl. pos. control) antibody

Detection of endogenous PAK4: Whole cell lysates of serum starved tumor cells (20.000 cells per lane) were applied to SDS-PAGE and transferred to PVDF membranes. Immunoblots were probed with AM20217PU-N PAK4 antibody (Clone 6C1) at 0.5 µg/ ml for 1h at RT and developed by ECL (exp. time: 30 sec).
Lane 1: A431 
Lane 2:SW480 
Lane 3: SW620
Lane 4: HT29 
Lane 5: MCF7 
Lane 6: MDA-MB-231 
Lane 7: T47D Mouse IgG1 6C1 Purified Can, Hu, Ms, Rt WB
0.1 mg / $450.00
  OriGene Technologies GmbH

2 Item(s)

per page
  • LinkedIn