MMP-16 antibody

Principal name

MMP-16 antibody

Alternative names for MMP-16 antibody

Matrix metalloproteinase-16, MMP-X2, MMP16, MMPX2, Membrane-type-3 matrix metalloproteinase

SwissProt ID

O35548 (Rat), P51512 (Human), Q9WTR0 (Mouse)

Gene ID

4325 (MMP16), 65205 (Mmp16)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Rb (Rabbit), Can (Canine), Mky (Monkey), Por (Porcine), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C)

Background of MMP-16 antibody

The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zinc endopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.
MMP16 induces the activation of pro gelatinase A (MMP2). It was identified as a membrane bound Metalloproteinase in normal and tumor cell lines. MMP16 is similar to the other MtMMPs; it contains a furin cleavage site, is membrane bound, and contains a cytoplasmic tail (MT4MMP lacks the tail, and may not be intercalated into the membrane). MMP16 is also known to be "shed" from the membrane in a soluble form. MT1MMP is known to function in activating a number of MMPs, chiefly MMP2, but that role has not been well described for the other MTMMPs. MMP16 has been reported to be elevated in several tumor cell lines, and is constituitively produced by some normal cell lines.

General readings

1. Hadchouel A  et al. Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development. PLoS ONE 3:e3188 (2008). WB ; Human . PubMed: 18784838

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MMP-16 antibody

  Rabbit polyclonal anti-MMP-16 antibody  
Western blot analysis of extracts from HepG2 cells, using MMP-16 antibody (#TA311662).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / $325.00
  OriGene Technologies, Inc.

MMP-16 antibody

  Rabbit Polyclonal Anti-MMP16 Antibody  
WB Suggested Anti-MMP16 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / $325.00
  OriGene Technologies, Inc.

MMP-16 antibody

  Rabbit Polyclonal Anti-MMP16 Antibody  
Western blot analysis on HepG2 cell lysate using MMP16 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / $325.00
  OriGene Technologies, Inc.

MMP-16 antibody

  Rabbit Polyclonal Anti-MMP16 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using (MMP16 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / $325.00
  OriGene Technologies, Inc.

MMP-16 antibody

Immunohistochemistry (IHC) analyzes of MMP-16  antibody (Cat.-No.: AP06229PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / $330.00
  Acris Antibodies GmbH

MMP-16 (169-183) antibody

Figure 1. Staining MMP16 in Spleen by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / $430.00
  Acris Antibodies GmbH

MMP-16 (C-term) antibody

MMP16 Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt C, P, WB
0.1 mg / $260.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

MMP16 overexpression lysate

MMP16 overexpression lysate  
0.1 mg / $280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MMP16 (mGFP-tagged) - Human matrix metallopeptidase 16 (membrane-inserted) (MMP16), 200 uL, >10^7 TU/mL

Lenti ORF particles, MMP16 (mGFP-tagged) - Human matrix metallopeptidase 16 (membrane-inserted) (MMP16), 200 uL, >10^7 TU/mL  
200 µl / $1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, MMP16 (mGFP-tagged) - Human matrix metallopeptidase 16 (membrane-inserted) (MMP16), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, MMP16 (mGFP-tagged) - Human matrix metallopeptidase 16 (membrane-inserted) (MMP16), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / $1,060.00
  OriGene Technologies, Inc.

Lenti ORF particles, MMP16 (Myc-DDK tagged) - Human matrix metallopeptidase 16 (membrane-inserted) (MMP16) , 200 uL, >10^7 TU/mL

Lenti ORF particles, MMP16 (Myc-DDK tagged) - Human matrix metallopeptidase 16 (membrane-inserted) (MMP16) , 200 uL, >10^7 TU/mL  
200 µl / $940.00
  OriGene Technologies, Inc.

Lenti ORF particles, MMP16 (Myc-DDK tagged) - Human matrix metallopeptidase 16 (membrane-inserted) (MMP16), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, MMP16 (Myc-DDK tagged) - Human matrix metallopeptidase 16 (membrane-inserted) (MMP16), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / $950.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Mmp16 (GFP-tagged ORF) - Rat matrix metallopeptidase 16 (Mmp16), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mmp16 (GFP-tagged ORF) - Rat matrix metallopeptidase 16 (Mmp16), 200 uL, >10^7 TU/mL  
200 µl / $1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, Mmp16 (Myc-DDK-tagged ORF) - Rat matrix metallopeptidase 16 (Mmp16), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mmp16 (Myc-DDK-tagged ORF) - Rat matrix metallopeptidase 16 (Mmp16), 200 uL, >10^7 TU/mL  
200 µl / $1,058.00
  OriGene Technologies, Inc.

14 Item(s)

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