DNMT3A antibody

Principal name

DNMT3A antibody

Alternative names for DNMT3A antibody

DNA MTase HsaIIIA, M.HsaIIIA, DNA (cytosine-5)-methyltransferase 3A, DNA methyltransferase HsaIIIA

SwissProt ID

O88508 (Mouse), Q1LZ53 (Rat), Q4W5Z4 (Chick), Q9Y6K1 (Human)

Gene ID

1788 (DNMT3A), 13435 (Dnmt3a), 444984

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Prim (Primate), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ChIP assay (ChIP), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of DNMT3A antibody

Methylation of D at cytosine residues in mammalian cells is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting and development. Three families of mammalian D methyltransferases have been identified: DNMT1, DNMT2 and DNMT3. DNMT1 is constitutively expressed in proliferating cells and functions as a maintence methyltransferase, transferring proper methylation patterns to newly synthesized D during replication. DNMT3A and DNMT3B are strongly expressed in embryonic stem cells with reduced expression in adult somatic tissues. DNMT3A and DNMT3B function as de novo methyltransferases that methylate previously unmethylated regions of D. DNMT2 is expressed at low levels in adult somatic tissues and its ictivation affects neither de novo nor maintence D methylation. DNMT1, DNMT3A and DNMT3B together form a protein complex that interacts with histone deacetylases (HDAC1, HDAC2, Sin3A), transcriptiol repressor proteins (RB, TAZ-1) and heterochromatin proteins (HP1, SUV39H1), to maintain proper levels of D methylation and facilitate gene silencing. Improper D methylation contributes to diseased states such as cancer. Hypermethylation of promoter CpG islands within tumor suppressor genes correlates with gene silencing and the development of cancer. In addition, hypomethylation of bulk genomic D correlates with and may contribute to the onset of cancer. DNMT1, DNMT3A and DNMT3B are over-expressed in many cancers, including acute and chronic myelogenous leukemias, in addition to colon, breast and stomach carcinomas.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DNMT3A antibody

  Rabbit Polyclonal DNMT3A Antibody  
Western Blot: Dnmt3a Antibody [TA336977] - Analysis of Dnmt3a in Dnmt3a transfected 293 cell lysate using TA336977 at 1 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. Rabbit Purified Hu, Prim WB
0.1 mg / $335.00
  OriGene Technologies, Inc.

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