GABA A Receptor Regulator of Excitability and Drug Ta - Product Review 22

The Ligand: GABA

Gamma-aminobutyric acid (GABA) is the most abundant and most important neurotransmitter of mammalian brain. GABA controls the degree of excitability in all brain regions, wheras the level of neuronal activity is regulated by the balance between excitatoric (mostly glutaminergic) and inhibotory (mostly GABA-ergic) signals. GABA exerty ist effects via GABA receptors, which come in three types: GABA A receptors, GABA B receptors and GABA C receptors.

GABA A Receptors

GABA A Receptors (GABAAR) are ligand-controlled chloride channels, composed of 5 subunits. Besides binding GABA, they also bind a number of drugs such as benzodiazepines and barbiturates, making them of primary interest for pharmacological and neurological studies.

GABAAR Subunits

Until now 16 different GABAAR subunits have been identified, which belong to 3 different groups: Alpha (1-6), beta (1-4) and gamma (1-4). In addition delta, epsilon, pie, theta and rho (1-6) subunits have been found. The subunit composition of GABAAR varies in different tissues and determines the pharmacological characteristics of the receptor.

GABAAR Antibodies

Acris Antibodies offers an exceedingly wide range of antibodies for detection of different GABAAR subunits. All antibodies have been tested for Western blot, but part of them also for other applications like ELISA, immunoprecipitation and immunohistochemistry.



Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).

Fig. 2: Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).



In the table below all our antibodies for detection of GABAAR are listed. All GABA A Receptor products: GABA A Receptor antibody, GAA1 antibody, GAA2 antibody, GAA3 antibody, GAA4 antibody, GAA5 antibody, GAA6 antibody, GAB1 antibody, GAB2 antibody, GAB3 antibody, GABRD antibody, GAE antibody, GAG2 antibody, GAG3 antibody, GABRP antibody



13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GABA antibody

Staining with GABA (gamma-Aminobutyric Acid) Antibody 20094 Rabbit Serum Ms, Re, Rt C, ICC/IF, P
0.1 ml / $410.00
  ImmunoStar Inc.

GABA antibody

Staining with GABA antibody (20095) Rabbit Serum Rt C, ICC/IF, P
0.1 ml / $205.00
  ImmunoStar Inc.

GABAA Receptor alpha 6 antibody

GABAA Receptor alpha 6 Rabbit IgG Purified Ms, Rt WB
0.1 ml / $630.00
  Acris Antibodies GmbH

GABRA1 antibody

GABRA1 Rabbit IgG Purified Bov, Can, Chk, Hu, Mky, Ms, Rt WB
0.1 ml / $620.00
  Acris Antibodies GmbH

GABRA1 (N-term) antibody

GABRA1 Rabbit IgG Purified Ms, Rt WB
0.1 ml / $630.00
  Acris Antibodies GmbH

GABRA4 (C-term) antibody

GABRA4 Rabbit IgG Purified Bov, Hu, Ms, Rt WB
0.1 ml / $630.00
  Acris Antibodies GmbH

GABRA5 (C-term) antibody

GABRA5 Rabbit IgG Purified Ms, Rt WB
0.1 ml / $620.00
  Acris Antibodies GmbH

GABRB1 antibody

Immunohistochemistry (IHC) analysis of GABA-RB antibody (Cat.-No.: AP06129PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / $330.00
  Acris Antibodies GmbH

GABRB1 antibody

Figure 1. Western blot analysis of extracts from PC12 cells using GABRB1 antibody AP08059PU (Lane 1 and 2). Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / $270.00
  Acris Antibodies GmbH

GABRB1 antibody

Figure 1. Western blot analysis of extracts from PC12 cells using GABRB1 antibody AP08059PU (Lane 1 and 2). Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / $205.00
  Acris Antibodies GmbH

GABRB2 (C-term) antibody

GABRB2 Rabbit IgG Purified Can, Hu, Mky, Ms, Rt WB
0.1 ml / $630.00
  Acris Antibodies GmbH

GABRD (N-term) antibody

GABRD Rabbit IgG Purified Ms, Rt C, IP, WB
0.1 ml / $700.00
  Acris Antibodies GmbH

GABRG2 antibody

GABRG2 Rabbit IgG Serum Chk, Hu, Mky, Ms, Rt, Ze WB
50 µl / $630.00
  Acris Antibodies GmbH

13 Item(s)

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