PA1277 Alpha-1-antitrypsin

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Product Description for Alpha-1-antitrypsin

Presentation: Purified

Properties for Alpha-1-antitrypsin

Product Category Proteins & Growth Factors
Target Category
Quantity 5 mg
Synonyms AAT, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, SERPINA1
Presentation Purified
Molecular weight 51 kDa
Source Plasma
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Swiss Prot Num:
Purity > 95 % Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Concentration 20 mg/ml
Storage Store the protein undiluted at 2-8°C.
Shelf life: one year from despatch.
Source Human Plasma
Alpha 1-proteinase inhibitor (human) is a serum glycoprotein synthesized in the liver. It acts as an elastase inhibitor, primarily inhibiting neutrophil elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. Human A1AT consists of a single polypeptide chain. It exists in a number of genetic variants. In the absence of Human A1AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Human API deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in Human A1AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of Human A1AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis. In colorectal and lung carcinomas, Human A1AT has also related to their invasive and metastatic capacity. The average level of Human A1AT in plasma is 1.3g/L.
Biological activity:
1-4 mg will inhibit 1.0 mg of trypsin with activity of 10,000 BAEE units per mg protein. 2-6 mg will inhibit approx.1.0 mg ofa-chymotrypsin with activity of 40-50 BTEE units per mg protein.
Molecular weight:
Buffer System:
0.5X PBS and 7mg sodium chloride
>95% Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Liquid purified protein (Sterile Filtered clear solution)
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