Antibody Panel to Parathyroid Hormone Receptors (PTHR) - FocusOn 063

Introduction

Parathyroid hormone receptors 1 and 2 are members of the G-protein coupled receptor family. The activity of these receptors are mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

Parathyroid hormone receptor 1 (PTHR1) is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Parathyroid hormone receptor 1 has been reported to be expressed in bone, breast, brain, colon, GI, kidney, liver, placenta, skin, umbilical cord, and uterus.

Parathyroid hormone receptor 2 (PTHR2) is a specific receptor for parathyroid hormone. It may be responsible for PTH effects in a number of physiological systems and may play a significant role in pancreatic function. Its presence in neurons indicates that it may function as a neurotransmitter receptor. ESTs have been isolated from normal testis libraries as well as cancer libraries from bone marrow, brain, germ cell, head/neck, and skin.

Antibody Tools for the Detection of Parathyroid Hormone Receptors

A panel of antibodies to PTHR1+2 is available at Acris Antibodies. Most of these antibodies are excellent for immunohistochemistry on paraffin embedded tissues.

Staining of human breast cancer using anti-PTHR1 antibody AM00336PU-NStaining of neurons and glia in human brain using anti-PTHR2 antibody SP4447P

Fig. 1: Staining of human breast cancer using anti-PTHR1 antibody AM00336PU-N

Fig. 2: Staining of neurons and glia in human brain using anti-PTHR2 antibody SP4447P

Available Antibody Panel to PTH Receptor

Parathyroid hormone receptor 1 (PTHR1) and Parathyroid hormone receptor 2 (PTHR2) antibody

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