AP01447PU-N PAK4/PAK5/PAK6 antibody

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Search for all "PAK4/PAK5/PAK6"

0.1 mg / $330.00
Delivery Time: 10 working days*
(*) valid for US customers only

Quick Overview

Rabbit anti Human, Mouse, Rat PAK4/PAK5/PAK6

Product Description for PAK4/PAK5/PAK6

Rabbit anti Human, Mouse, Rat PAK4/PAK5/PAK6.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for PAK4/PAK5/PAK6

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms KIAA1142, KIAA1264, PAK 4, PAK-4, PAK-5, PAK-5, PAK-6, PAK-7, PAK5, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PAK 6, Serine/threonine-protein kinase PAK 7, p21-activated kinase 4, p21-activated kinase 5, p21-activated kinase 6, p21-activated kinase 7
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Molecular weight ~ 80 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
O96013
GeneID:
10298
Application Western Blot: 1/500-1/1000.
Background Three recently identified isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gammaPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiaekinase STE20, involved in pheromone signaling. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates. One such putative substrate is MEK kinase, an upstream effector of MEK4 which is involved in the JNK signaling pathway. While the PAK isoforms interact in a GTP-dependent manner with Rac1 and Cdc42, they do not interact with Rho.
Concentration 1.0 mg/ml
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity Chromatography using epitope-specific immunogen.
Buffer System:
Phosphate buffered saline (PBS) with 0.05% Sodium Azide as preservative, approx. pH 7.2.
State:
Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Mouse and Rat.
Specificity
Specificity:
PAK4/5/6 antibody detects endogenous levels of PAK4/5/6 protein.(region surrounding Val469)
Gene ID 10298

Accessory Products

Proteins and/or Positive Controls

Proteins for PAK4/PAK5/PAK6 (7 products)

Catalog No. Species Pres. Purity   Source  

PAK4 (transcript variant 1)

PAK4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / $680.00
  OriGene Technologies, Inc.

PAK4 (transcript variant 2)

PAK4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / $438.00
  OriGene Technologies, Inc.

PAK4 (transcript variant 3)

PAK4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / $680.00
  OriGene Technologies, Inc.

PAK4 (transcript variant 1)

PAK4 Human > 90 %
Preparation: .
Purity Detail: >90% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / $143.00
  OriGene Technologies, Inc.

PAK4 (transcript variant 1)

PAK4 Human > 90 %
Preparation: .
Purity Detail: >90% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
0.1 mg / $1,050.00
  OriGene Technologies, Inc.

PAK4 (1-591, His-tag)

PAK4 Human Purified > 90 % by SDS PAGE E. coli
0.5 mg / $1,010.00
  OriGene Technologies GmbH

PAK4 (1-591, His-tag)

PAK4 Human Purified > 90 % E. coli
0.1 mg / $410.00
  OriGene Technologies GmbH
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