TA319771 LRRFIP1 (C-term) antibody

Rabbit Polyclonal LRRFIP1 Antibody

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Search for all "LRRFIP1"

0.1 mg / $371.00
Delivery Time: 5-7 working days*
(*) valid for US customers only

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Rabbit anti Human LRRFIP1

TA319771

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Product Description for LRRFIP1

Rabbit anti Human LRRFIP1.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for LRRFIP1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms GC-binding factor 2, GCF2, LRR FLII-interacting protein 1, Leucine-rich repeat flightless-interacting protein 1, TAR RNA-interacting protein, TRIP
Presentation Aff - Purified
Reactivity Hu
Applications E, WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q32MZ4
Immunogen:
19 amino acid peptide near the carboxy terminus of human LRRFIP1
GeneID:
9208
Property C-term
Application ELISA.
Western blot: 1-2 µg/ml.
Positive control: Human Colon Tissue Lysate.
Background LRRFIP1, also known as GC-binding factor 2 (GCF2), is a 738 amino acid transcriptional repressor that mainly plays a cytoskeletal role. It is primarily localized in the cytoplasm and preferentially binds to GC-rich dsDNA, but will also bind directly to dsRNA as well. The RNA binding domain encompasses a lysine-rich motif. LRRFIP1 interacts with the mammalian Flightless I (Fli-I) and is a key component in the cytoskeletal regulation of platelet function. LRRFIP1 and the related protein LRRFIP2 may modulate canonical WNT signaling and mediate the IRF3-induced production of type I interferon via a B-catenin-dependent pathway.
General Readings
  1. Rikiyama T, Curtis J, Oikawa M, Zimonjic DB, Popescu N, Murphy BA, et al. GCF2: expression and molecular analysis of repression. Biochim Biophys Acta. 2003 Oct 1;1629(1-3):15-25. PubMed PMID: 14522076.
  2. Suriano AR, Sanford AN, Kim N, et al. GCF2/LRRFIP1 represses tumor necrosis factor ? expression. Mol. Cell. Biol. 2005; 25:9073-81.
  3. Wilson SA, Brown EC, Kingsman AJ, Kingsman SM. TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I. Nucleic Acids Res. 1998 Aug 1;26(15):3460-7. PubMed PMID: 9671805. (Free PMC Article available)
  4. Goodall AH, Burns P, Salles I, Macaulay IC, Jones CI, Ardissino D, et al. Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function. Blood. 2010 Nov 25;116(22):4646-56. doi: 10.1182/blood-2010-04-280925. Epub 2010 Sep 10. PubMed PMID: 20833976. (Free PMC Article available, 6 images available)
Storage Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide
State:
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:
This antibody detects LRRFIP1 at C-term.
LRRFIP1 antibody is predicted to not cross-react with other LRRFIP family members. Three isoforms of LRRFIP1 are known to exist; this antibody will only recognize the two longer isoforms.

Accessory Products

Proteins and/or Positive Controls

Proteins for LRRFIP1 (1 products)

Catalog No. Species Pres. Purity   Source  

LRRFIP1 (transcript variant 4)

LRRFIP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / $680.00
  OriGene Technologies, Inc.

Positive controls for LRRFIP1 (1 products)

Catalog No. Species Pres. Purity   Source  

LRRFIP1 overexpression lysate

LRRFIP1 overexpression lysate
0.1 mg / $495.00
  OriGene Technologies, Inc.
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