SM1747P Influenza A (Nucleoprotein) antibody

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Mouse anti Human Influenza A (Nucleoprotein) AA5H


Product Description for Influenza A (Nucleoprotein)

Mouse anti Human Influenza A (Nucleoprotein) AA5H.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence.

Properties for Influenza A (Nucleoprotein)

Product Category Primary Antibodies
Quantity 1 mg
Presentation Purified
Reactivity Hu
Applications ICC/IF
Clonality Monoclonal
Clone AA5H
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Influenza A / Puerto Rico / 8 / 34 (H1N1) and A/Bangkok / 1 / 79 (H3N2) viruses.
Spleen cells from BALB/c mice were fused with cells of the P3 Ag8.653 mouse myeloma cell line.
Isotype control AM03096PU-N
Application Immunofluorescence.
Background Influenza A virus is a major public health threat. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes.
In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells.
Concentration 1.0 mg/ml
General Readings
  1. Herold S, von Wulffen W, Steinmueller M, Pleschka S, Kuziel WA, Mack M, et al. Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules. J Immunol. 2006 Aug 1;177(3):1817-24. PubMed PMID: 16849492.
  2. Ehrhardt C, Wolff T, Pleschka S, Planz O, Beermann W, Bode JG, et al. Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses. J Virol. 2007 Apr;81(7):3058-67. Epub 2007 Jan 17. PubMed PMID: 17229704. (Free PMC Article available, 6 images available)
  3. Ehrhardt C, Wolff T, Ludwig S. Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses. J Virol. 2007 Nov;81(21):12097-100. Epub 2007 Aug 22. PubMed PMID: 17715214. (Free PMC Article available, 3 images available)
  4. Matarrese P, Nencioni L, Checconi P, Ciarlo L, Gambardella L, Ascione B, et al. Pepstatin A alters host cell autophagic machinery and leads to a decrease in influenza A virus production. J Cell Physiol. 2011 Dec;226(12):3368-77. doi: 10.1002/jcp.22696. PubMed PMID: 21344392.
  5. Nencioni L, De Chiara G, Sgarbanti R, Amatore D, Aquilano K, Marcocci ME, et al. Bcl-2 expression and p38MAPK activity in cells infected with influenza A virus: impact on virally induced apoptosis and viral replication. J Biol Chem. 2009 Jun 5;284(23):16004-15. doi: 10.1074/jbc.M900146200. Epub 2009 Mar 31. PubMed PMID: 19336399. (Free PMC Article available, 7 images available)
  6. Pauli EK, Schmolke M, Wolff T, Viemann D, Roth J, Bode JG, et al. Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression. PLoS Pathog. 2008 Nov;4(11):e1000196. doi: 10.1371/journal.ppat.1000196. Epub 2008 Nov 7. PubMed PMID: 18989459. (Free PMC Article available, 8 images available)
  7. Jamali A, Sabahi F, Bamdad T, Hashemi H, Mahboudi F, Kheiri MT. A DNA vaccine-encoded nucleoprotein of influenza virus fails to induce cellular immune responses in a diabetic mouse model. Clin Vaccine Immunol. 2010 Apr;17(4):683-7. doi: 10.1128/CVI.00445-09. Epub 2010 Feb 17. PubMed PMID: 20164252. (Free PMC Article available, 5 images available)
  8. Ehrhardt C, Hrincius ER, Korte V, Mazur I, Droebner K, Poetter A, et al. A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance. Antiviral Res. 2007 Oct;76(1):38-47. Epub 2007 Jun 4. PubMed PMID: 17572513.
  9. Seitz C, Frensing T, Höper D, Kochs G, Reichl U. High yields of influenza A virus in Madin-Darby canine kidney cells are promoted by an insufficient interferon-induced antiviral state. J Gen Virol. 2010 Jul;91(Pt 7):1754-63. doi: 10.1099/vir.0.020370-0. Epub 2010 Mar 31. PubMed PMID: 20357039.
  10. Gabay, C. et al. (2011) Impact of synthetic and biological disease modifying antirheumatic drugs on antibody responses to the ASO3-adjuvanted pandemic influenza vaccine. Arthritis Rheum. Mar 7.. [Epub ahead of print]
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity Chromatography on Protein A
Buffer System:
PBS containing 0.09% Sodium Azide as preservative
Liquid purified IgG fraction
This antibody recognises an epitope within Influenza virus A Bucleoprotein.
This antibody can be used in Influenza A IFA typing in conjunction with SM1748P (clone GA2B).

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