AP31330PU-N DPYSL2 / CRMP2 (C-term) antibody

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50 µl / $425.00
Delivery Time: 5-7 working days*
(*) valid for US customers only

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Rabbit anti Human, Mouse, Rat DPYSL2 / CRMP2


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Product Description for DPYSL2 / CRMP2

Rabbit anti Human, Mouse, Rat DPYSL2 / CRMP2.
Properties: (C-term)
Presentation: Purified
Product is tested for Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.

Properties for DPYSL2 / CRMP2

Product Category Primary Antibodies
Target Category
Quantity 50 µl
Synonyms Collapsin response mediator protein 2, DRP-2, Dihydropyrimidinase-related protein 2, N2A3
Presentation Purified
Reactivity Hu, Ms, Rt
Applications E, ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
Synthetic peptide - KLH conjugated
Antigen Modification: C-Terminus
Property C-term
Application ELISA: 1/1000.
Immunofluorescence: 1/100 - 1/500.
Immunohistochemistry on Paraffin Sections: 1/100.
Western Blot: 1/500 - 1/1000.
Background DRP-2, also known as Collapsin Response Mediator Protein-2 (CRMP-2), is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity. CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly. GSK-3b inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3b. Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway. CRMP-2 also mediates semaphorin-induced growth cone collapse. Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3b activity in these patients.
Concentration 1.0 mg/ml
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Immunoaffinity Chromatography.
Buffer System:
PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol.
Liquid purified IgG fraction.
Species Reactivity
Species reactivity (expected):
Mouse and Rat.
Species reactivity (tested):
This antibody detects endogenous levels of total DPYSL2 protein.
Gene ID 1808

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