AP31330PU-N DPYSL2 / CRMP2 (C-term) antibody

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50 µl / $330.00
Delivery Time: 5-7 working days*
(*) valid for US customers only

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Rabbit anti Human, Mouse, Rat DPYSL2 / CRMP2

AP31330PU-N

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Product Description for DPYSL2 / CRMP2

Rabbit anti Human, Mouse, Rat DPYSL2 / CRMP2.
Properties: (C-term)
Presentation: Purified
Product is tested for Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.

Properties for DPYSL2 / CRMP2

Product Category Primary Antibodies
Target Category
Quantity 50 µl
Synonyms Collapsin response mediator protein 2, DRP-2, Dihydropyrimidinase-related protein 2, N2A3
Presentation Purified
Reactivity Hu, Ms, Rt
Applications E, ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q16555
Immunogen:
Synthetic peptide - KLH conjugated
GeneID:
1808
Remarks:
Antigen Modification: C-Terminus
Property C-term
Application ELISA: 1/1000.
Immunofluorescence: 1/100 - 1/500.
Immunohistochemistry on Paraffin Sections: 1/100.
Western Blot: 1/500 - 1/1000.
Background DRP-2, also known as Collapsin Response Mediator Protein-2 (CRMP-2), is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity. CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly. GSK-3b inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3b. Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway. CRMP-2 also mediates semaphorin-induced growth cone collapse. Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3b activity in these patients.
Concentration 1.0 mg/ml
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Immunoaffinity Chromatography.
Buffer System:
PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol.
State:
Liquid purified IgG fraction.
Purified
Species Reactivity
Species reactivity (expected):
Mouse and Rat.
Species reactivity (tested):
Human.
Specificity
Specificity:
This antibody detects endogenous levels of total DPYSL2 protein.
Gene ID 1808

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