AM11031SU-N DPYSL2 / CRMP2 antibody

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0.4 ml / $330.00
Delivery Time: 5-7 working days*
(*) valid for US customers only

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Mouse anti Human DPYSL2 / CRMP2 33CT11.40.3

AM11031SU-N

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Product Description for DPYSL2 / CRMP2

Mouse anti Human DPYSL2 / CRMP2 33CT11.40.3.
Presentation: Ascites
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for DPYSL2 / CRMP2

Product Category Primary Antibodies
Target Category
Quantity 0.4 ml
Synonyms Collapsin response mediator protein 2, DRP-2, Dihydropyrimidinase-related protein 2, N2A3
Presentation Ascites
Reactivity Hu
Applications P, WB
Clonality Monoclonal
Clone 33CT11.40.3
Host Mouse
Isotype IgG2b
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q16555
Immunogen:
Purified recombinant DHP fusion protein.
GeneID:
1808
Application ELISA: 1/1,000.
Western blotting: 1/500-1/1000.
Immunohistochemistry on Paraffin Sections: 1/200.
Background DRP-2, also known as collapsin response mediator protein-2 (CRMP-2), is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity (1,2). CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly (3). GSK-3β inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3β (2). Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway (2). CRMP-2 also mediates semaphorin-induced growth cone collapse (4). Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3β activity in these patients (5).
General Readings
  1. Hamajima,N., Gene 180 (1-2), 157-163 (1996)
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
State:
Ascites containing 0.09% (W/V) Sodium Azide as preservative.
Ascites
Specificity
Specificity:
This antibody is specific to DRP-2.
Species:
Human and Mouse.
Gene ID 1808

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