TA327291 Cullin 1 antibody

CUL1 Rabbit Polyclonal Antibody

See related secondary antibodies

Search for all "Cullin 1"

0.1 mg / $335.00
Delivery Time: 4-5 weeks*
(*) valid for US customers only

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Rabbit anti Human, Mouse, Rat Cullin 1


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  • TA327291

Product Description for Cullin 1

Rabbit anti Human, Mouse, Rat Cullin 1.
Presentation: Purified

Properties for Cullin 1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms CUL-1, CUL1, Cullin-1
Presentation Purified
Reactivity Hu, Ms, Rt
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Swiss Prot Num:
Recombinant protein of human CUL1.
Application WB 1:500 - 1:2000
IHC 1:50- 1:200
Background Ubiquitin can be covalently linked to many cellular proteins by the ubiquitition process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target protein-ubiquitin conjugation process. Ubiquitin is first activated by forming a thiolester complex with the activation component E1; the activated ubiquitin is subsequently transferred to the ubiquitin-carrier protein E2, then from E2 to ubiquitin ligase E3 for fil delivery to the epsilon-NH2 of the target protein lysine residue. Combitorial interactions of different E2 and E3 proteins result in substrate specificity. Recent data suggest that activated E2 associates transiently with E3, and that the dissociation is a critical step for ubiqitition. Cullin homolog 1 (CUL1), the mammalian homolog of Cdc53 from yeast, is a molecular scaffold of the SCF (Skp1/CUL1/F-box) E3 ubiquitin ligase protein complex. Thus, CUL1 and its family members function in ubiquitin dependent proteolysis. In particular, CUL1 has been shown to mediate ubiquitin dependent degradation of p21 Waf1/Cip1, cyclin D and IkappaB-alpha.
Affinity purification
Buffer System:
Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Accessory Products

Proteins and/or Positive Controls

Proteins for Cullin 1 (3 products)

Catalog No. Species Pres. Purity   Source  

Cullin 1

Cullin 1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / $748.00
  OriGene Technologies, Inc.

Cullin 1 (1-410, His-tag)

Recombinant human CUL1, 1- 410 aa, His-tagged Human Purified > 95 % E. coli
0.25 mg / $820.00
  OriGene Technologies GmbH

Cullin 1 (1-410, His-tag)

Recombinant human CUL1, 1- 410 aa, His-tagged Human Purified > 95 % E. coli
50 µg / $320.00
  OriGene Technologies GmbH
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