SM1161F CD79a antibody

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0.1 mg / $490.00
Delivery Time: 3-5 working days*
(*) valid for US customers only

Quick Overview

Mouse anti Human CD79a ZL7-4

Product Description for CD79a

Mouse anti Human CD79a ZL7-4.
Presentation: FITC
Product is tested for Flow Cytometry.

Properties for CD79a

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms B-Cell marker, B-cell antigen receptor complex-associated protein alpha-chain, IGA, MB-1 membrane glycoprotein, MB1, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein
Presentation FITC
Reactivity Hu
Applications F
Clonality Monoclonal
Clone ZL7-4
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P11912
Immunogen:
IgM complex isolated from Daudi cells. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
GeneID:
973
Isotype control SM10F (for use in human samples)
Application Flow Cytometry: Use 10 µl of neat antibody to label 1x10e6 cells in 100µl. We recommend incubation times of at least 30 minutes with this antibody.
Background A disulfide-linked heterodimer, consisting of CD79a / mb1 and CD79b / B29 polypeptides, is non-covalently associated with membrane bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79a first appears at pre B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). Induction of tyrosine kinase activity after antigen binding causes phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signaling.
Concentration 0.1 mg/ml
General Readings
  1. Zhang L, French RR, Chan HT, O'Keefe TL, Cragg MS, Power MJ, et al. The development of anti-CD79 monoclonal antibodies for treatment of B-cell neoplastic disease. Ther Immunol. 1995 Aug;2(4):191-202. PubMed PMID: 9358611.
  2. Bell PB, Rooney N, Bosanquet AG. CD79a detected by ZL7.4 separates chronic lymphocytic leukemia from mantle cell lymphoma in the leukemic phase. Cytometry. 1999 Jun 15;38(3):102-5. PubMed PMID: 10397328.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Label:
Fluorescein Isothiocyanate Isomer 1
FITC
Buffer System:
PBS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
State:
Liquid purified IgG fraction.
Specificity
Specificity:
This antibody reacts with CD79a positive cells by flow cytometry.
This clone has been reported to be useful in distinguishing B-CLL from mantle cell lymphoma in flow cytometric assays.
Species:
Human.
Gene ID 973

Accessory Products

Proteins and/or Positive Controls

Proteins for CD79a (1 products)

Catalog No. Species Pres. Purity   Source  

CD79a (transcript variant 1)

CD79a Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / $748.00
  OriGene Technologies, Inc.

Positive controls for CD79a (1 products)

Catalog No. Species Pres. Purity   Source  

CD79A overexpression lysate

CD79A overexpression lysate
0.1 mg / $295.00
  OriGene Technologies, Inc.
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